---
title: Can increasing methadone during the premenstrual period help PMS symptoms?
description: One woman improved in her premenstrual symptoms when her methadone dose was increased during her premenstrual period. This is one person's experience, so we c
url: https://niyora.com/research/papers/premenstrual-syndrome-and-self-medication-with-opioids-2013/
---

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- Can increasing methadone during the premenstrual period help PMS symptoms?

Case report, 2013

# Can increasing methadone during the premenstrual period help PMS symptoms?

One woman improved in her premenstrual symptoms when her methadone dose was increased during her premenstrual period. This is one person's experience, so we can't be sure it would work for others.

 Early or limited evidence

One woman with PMS in treatment for opioid addiction

## What they did

Doctors tracked one woman in treatment for opioid addiction who was using heroin to try to manage her premenstrual symptoms. They increased her methadone (the medication she was taking for addiction treatment) during her premenstrual period.

## What they found

Increasing the methadone during her premenstrual period produced significant improvement in her premenstrual symptoms.

## What it means for you

This is one woman's experience. The case suggests opioid receptors might be involved in premenstrual symptoms, but this is not a standard treatment and needs careful medical supervision.

## About the study

Original title Premenstrual syndrome and self-medication with opioids Authors Qurishi R, Sonneborn C, de Jong-Arts M et al. Journal Journal of addiction medicine Year 2013 Study design Case report What was tested Increased methadone dose during the premenstrual period Read the paper [doi.org/10.1097/adm.0b013e31827884a3](https://doi.org/10.1097/adm.0b013e31827884a3)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Cohort study, 2026

What genetic factors are linked to premenstrual symptoms?

Systematic review, 2026

How often do mood disorders and PMS or PMDD occur together?

Systematic review, 2026

Does vitamin D supplementation help PMS symptoms?

Study, 2026

How do women with PMDD process emotions differently in their brains?

Systematic review, 2026

Why do some women experience mood changes linked to their menstrual cycle?

Systematic review, 2026

How much of PMDD treatment improvement comes from placebo effect?

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