---
title: What treatments are proven to work for PMS? | Niyora
description: Recent trials show serotonergic antidepressants and gonadotropin-releasing hormone agonists effectively treat PMS. Preliminary evidence supports spironolacton
url: https://niyora.com/research/papers/premenstrual-syndrome-current-perspectives-on-treatment-and-etiology-1997/
---

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- What treatments are proven to work for PMS?

Randomised trial, 1997

# What treatments are proven to work for PMS?

Recent trials show serotonergic antidepressants and gonadotropin-releasing hormone agonists effectively treat PMS. Preliminary evidence supports spironolactone and carbohydrate-rich beverages.

 Early or limited evidence

Not a specific study. This is a review of PMS research.

## What they did

This is a literature review article that summarizes recent randomized controlled trials testing PMS treatments and discusses neuroendocrine research findings.

## What they found

Randomized trials showed that serotonergic antidepressants and gonadotropin-releasing hormone agonist are effective treatments. Preliminary data suggested benefit from spironolactone and carbohydrate-rich beverages. Multiple neuroendocrine studies reported findings suggesting an underlying neurobiological vulnerability in PMS.

## What it means for you

Multiple treatment approaches have been tested in recent research. Some are well-proven (antidepressants, hormone therapy) while others show only preliminary promise. This review was published in 1997 and newer treatments may now be available.

## About the study

Original title Premenstrual syndrome: current perspectives on treatment and etiology Authors Freeman EW Journal Current opinion in obstetrics & gynecology Year 1997 Study design Randomised trial What was tested Antidepressants, hormone agonist, spironolactone, carbohydrate-rich beverages Read the paper [https://pubmed.ncbi.nlm.nih.gov/9263696/](https://pubmed.ncbi.nlm.nih.gov/9263696/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)[Diuretics and other drugs](https://niyora.com/research/topics/treatment-diuretics-other-drugs/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Systematic review, 2007

What treatments work for premenstrual syndrome?

Randomised trial, 2003

What treatments work for PMS and PMDD?

Review, 2002

What treatments work best for PMS and PMDD?

Review, 2001

What are PMS and PMDD, and how are they treated?

Study, 1997

What medications work best for treating PMS?

Randomised trial, 2006

Do different types of PMS symptoms respond better to different medicines?

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