---
title: What treatments help PMS and PMDD? | Niyora
description: Both medications (SSRIs, hormonal therapy) and non-drug approaches (therapy, mindfulness, supplements, herbal medicine) show promise for PMS and PMDD. More re
url: https://niyora.com/research/papers/premenstrual-syndrome-pms-a-review-of-pharmacological-and-non-pharmacological-2025/
---

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- What treatments help PMS and PMDD?

Non-randomised trial, 2025

# What treatments help PMS and PMDD?

Both medications (SSRIs, hormonal therapy) and non-drug approaches (therapy, mindfulness, supplements, herbal medicine) show promise for PMS and PMDD. More research is needed to know which works best for whom.

 Moderate study design

Review of research on women of reproductive age with PMS or PMDD

## What they did

They reviewed recent research studies and reviews about treatments for PMS and PMDD.

## What they found

SSRIs, hormonal therapies, sepranolone, and ulipristal acetate reduce symptoms. CBT, mindfulness-based interventions, nutritional supplements, herbal medicine, and open-label placebos also work. More research is needed.

## What it means for you

Women have options beyond medication alone, including therapy and natural approaches. The main limit is that this reviews existing studies rather than providing new data, and the authors say better quality research is needed to know which treatments work best for different people.

## About the study

Original title PREMENSTRUAL SYNDROME (PMS) – A REVIEW OF PHARMACOLOGICAL AND NON-PHARMACOLOGICAL TREATMENT APPROACHES Authors Aleksandra Białas, Weronika Lusarczyk, Natalia Sapeda et al. Journal International Journal of Innovative Technologies in Social Science Year 2025 Study design Non-randomised trial What was tested Review of SSRIs, hormonal therapies, CBT, mindfulness, supplements, herbal medicine, and other treatments Open access Yes Read the paper [doi.org/10.31435/ijitss.3(47).2025.4010](https://doi.org/10.31435/ijitss.3(47).2025.4010) Original abstract

Premenstrual Syndrome (PMS) and its severe form, Premenstrual Dysphoric Disorder (PMDD), are prevalent cyclical disorders affecting the emotional, behavioral, and physical well-being of women of reproductive age. This review aims to present an overview of the current understanding of PMS/PMDD and critically examine both pharmacological and non-pharmacological treatment methods. Based on recent clinical trials and systematic reviews, selective serotonin reuptake inhibitors (SSRIs), hormonal therapies, and emerging drugs like sepranolone and ulipristal acetate demonstrate efficacy in symptom reduction (Bäckström et al., 2021; Comasco et al., 2020; Maranho et al., 2023). Simultaneously, cognitive-behavioral therapy (CBT), mindfulness-based interventions, nutritional supplements, herbal medicine, and even open-label placebos are gaining attention as effective non-pharmacological alternatives (Frey Nascimento et al., 2025; Reilly et al., 2023; Shojiasi et al., 2024; Sultana et al., 2022). Despite promising findings, further high-quality research is needed to tailor personalized and integrative treatment strategies.

Reproduced under CC-BY.

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Cognition, concentration and memory](https://niyora.com/research/topics/symptom-cognition/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)[Neurosteroids (allopregnanolone)](https://niyora.com/research/topics/treatment-neurosteroids/)[Cognitive behavioral therapy](https://niyora.com/research/topics/treatment-cbt/)[Mindfulness and meditation](https://niyora.com/research/topics/treatment-mindfulness/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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What non-hormonal medications and therapies help severe PMS and PMDD?

Randomised trial, 2026

How should PMS and PMDD be understood and treated differently based on how severe they are?

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