--- title: Does a birth control pill with estetrol and drospirenone help PMS? description: Yes. Over 3 months, this combination birth control significantly improved PMS symptoms and hormone levels. Non-hormonal therapy also helped but had smaller ef url: https://niyora.com/research/papers/premenstrual-syndrome-possibilities-of-correction-of-hormonal-homeostasis-and-2026/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does a birth control pill with estetrol and drospirenone help PMS? Cohort study, 2026 # Does a birth control pill with estetrol and drospirenone help PMS? Yes. Over 3 months, this combination birth control significantly improved PMS symptoms and hormone levels. Non-hormonal therapy also helped but had smaller effects. Moderate study design 78 women with PMS in comparison and treatment groups, plus 118 healthy women ## What they did 78 women with PMS were divided into two groups: 46 received non-hormonal therapy and 32 used a birth control pill containing estetrol and drospirenone. A control group of 118 healthy women was also studied. Treatments lasted 3 months and measurements were taken before and after. ## What they found In the birth control group, most PMS symptoms significantly decreased, all hormone levels increased and approached the healthy control group's levels, and depression and anxiety measures improved. The non-hormonal group also improved but with smaller changes in hormones. ## What it means for you This birth control combination appeared more effective than non-hormonal treatment for PMS symptoms and hormone balance. However, the two groups received different treatments, making direct comparison difficult. Results are from one study. 3 months treatment duration 32 women in E4/drospirenone group 46 women in non-hormonal group ## About the study Original title Premenstrual syndrome: possibilities of correction of hormonal homeostasis and mental health disorders with the use of a combined oral contraceptive with estetrol and drospirenone Authors Galina Ivanovna Reznichenko, N. Yu. Reznichenko, O. Gordiіchuk et al. Journal Reproductive health of woman Year 2026 Study design Cohort study Participants 118 What was tested Birth control pill containing estetrol and drospirenone for 3 months Open access Yes Read the paper [doi.org/10.30841/2708-8731.2.2026.359223](https://doi.org/10.30841/2708-8731.2.2026.359223) Original abstract The objective: to study the effectiveness of a drug containing estetrol (Е4) and drospirenone in the treatment of patients with premenstrual syndrome (PMS) and its impact on hormonal homeostasis, mental health, and quality of life.Materials and methods. 78 patients with PMS were divided into 2 groups: comparison group – 46 women who received non-hormonal therapy for 3 months and study group – 32 patients who used a drug containing Е4 and drospirenone for 3 months. Control group consisted of 118 healthy women. All patients were examined before and after treatment. The levels of serotonin, prolactin, follicle stimulating hormone, luteinizing hormone, cortisol, estradiol, progesterone in blood serum were determined; in daily urine – dopamine, adrenaline, noradrenaline; mental health and quality of life were studied.Results. In the comparison group, after therapy, the percentage of increased irritability/aggression significantly decreased and the dopamine level significantly increased and the levels of estradiol, adrenaline, noradrenaline, cortisol and perceived stress significantly decreased. In the study group, most of PMS clinical manifestations significantly decreased and the levels of all hormones significantly increased compared to the initial data and approached the results of the control group. Also, the indicators of neuroticism, depression and integral assessment of asthenia significantly decreased and the quality of life improved.Conclusions. In patients with PMS, before treatment, significant disorders in the homeostasis of the hormonal system were found; indicators of stress, neuroticism, asthenia and depression increased significantly and quality of life – decreased. Three-month therapy with non-hormonal drugs did not allow to restore the clinical, hormonal and mental state of women with PMS. The use of a drug containing Е4 and drospirenone in the treatment of PMS patients for 3 months significantly improved the patient’s state and hormonal level and led the indices closer to the results in the control group, which contributed to the normalization of mental health and quality of life of patients in this cohort. Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Irritability and anger](https://niyora.com/research/topics/symptom-irritability-anger/)[Stress](https://niyora.com/research/topics/symptom-stress/)[Oral contraceptives and drospirenone](https://niyora.com/research/topics/treatment-hormonal-contraceptives/)[Quality of life and daily functioning](https://niyora.com/research/topics/life-area-quality-of-life/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Cohort study, 2022 What are PMS and PMDD and how should they be diagnosed and treated? Randomised trial, 2017 Does Sepranolone reduce symptoms of severe premenstrual syndrome (PMDD)? 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