---
title: Can a GnRH analogue stop premenstrual attacks of hereditary coproporphyria?
description: Yes. In this one woman, the GnRH analogue stopped her menstrual cycle and her symptoms got much better. She has had only a minor attack once in 5 years but de
url: https://niyora.com/research/papers/prevention-of-premenstrual-exacerbation-of-hereditary-coproporphyria-by-1999/
---

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- Can a GnRH analogue stop premenstrual attacks of hereditary coproporphyria?

Case report, 1999

# Can a GnRH analogue stop premenstrual attacks of hereditary coproporphyria?

Yes. In this one woman, the GnRH analogue stopped her menstrual cycle and her symptoms got much better. She has had only a minor attack once in 5 years but developed weaker bones.

 Early or limited evidence

One 20-year-old woman with hereditary coproporphyria

## What they did

Case report of a 20-year-old woman with hereditary coproporphyria. She needed frequent hospitalization due to premenstrual attacks. She was given intranasal buserelin acetate, a GnRH analogue that stops menstrual cycles.

## What they found

Her symptoms improved dramatically once she stopped having periods. Urinary porphyrin derivatives fell markedly. She remained free from major attacks but had a minor attack once in 5 years. Her bones became weaker (osteopenia) as a side effect of long-term treatment.

## What it means for you

Stopping the menstrual cycle with this hormone medicine can improve symptoms. However, long-term use can weaken bones, which is a concern. This is one woman's experience.

20

age in years

once in 5 years

frequency of minor attacks after treatment

## About the study

Original title Prevention of premenstrual exacerbation of hereditary coproporphyria by gonadotropin-releasing hormone analogue Authors Yamamori I, Asai M, Tanaka F et al. Journal Internal medicine (Tokyo, Japan) Year 1999 Study design Case report What was tested Intranasal buserelin acetate (GnRH analogue) Open access Yes Read the paper [doi.org/10.2169/internalmedicine.38.365](https://doi.org/10.2169/internalmedicine.38.365)

## Topics

[Premenstrual exacerbation (PME)](https://niyora.com/research/topics/condition-pme/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)

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