---
title: How do brain receptors change in different types of PMDD? | Niyora
description: Rats with two different types of PMDD showed different changes in brain receptors and brain chemicals, suggesting PMDD might have different forms.
url: https://niyora.com/research/papers/profiling-gaba-a-receptor-subunit-expression-in-the-hippocampus-of-pmdd-rat-2023/
---

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- How do brain receptors change in different types of PMDD?

Lab study, 2023

# How do brain receptors change in different types of PMDD?

Rats with two different types of PMDD showed different changes in brain receptors and brain chemicals, suggesting PMDD might have different forms.

 Early or limited evidence

Rats with two types of induced PMDD models

## What they did

Researchers created two types of PMDD rat models based on traditional Chinese medicine categories. They measured different brain receptors and brain chemicals (GABA and glutamate) in the hippocampus.

## What they found

The two types of rats showed different patterns of receptor changes. In one type, GABA (a calming chemical) decreased while glutamate (an activating chemical) increased.

## What it means for you

Different types of PMDD might have different causes in the brain. If this is true in people, it might mean different treatments work for different women. The main limit is this was animal research, not human studies.

## About the study

Original title Profiling GABA(A) Receptor Subunit Expression in the Hippocampus of PMDD Rat Models Based on TCM Theories Authors Zhang H, Gao Z, Sun Y et al. Journal Molecular neurobiology Year 2023 Study design Lab study What was tested Observation of two PMDD model types Read the paper [doi.org/10.1007/s12035-023-03354-3](https://doi.org/10.1007/s12035-023-03354-3)

## Topics

[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Neurosteroids (allopregnanolone)](https://niyora.com/research/topics/treatment-neurosteroids/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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