--- title: What brain proteins change during premenstrual irritability? | Niyora description: In rats with PMS irritability, researchers found changes in many brain proteins in the hypothalamus and hippocampus, with some proteins decreasing and others url: https://niyora.com/research/papers/profiling-proteins-in-the-hypothalamus-and-hippocampus-of-a-rat-model-of-2017/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - What brain proteins change during premenstrual irritability? Lab study, 2017 # What brain proteins change during premenstrual irritability? In rats with PMS irritability, researchers found changes in many brain proteins in the hypothalamus and hippocampus, with some proteins decreasing and others increasing, providing new insights into premenstrual irritability. Early or limited evidence Rat models of PMS irritability ## What they did Researchers used lab techniques to measure proteins in two brain areas (hypothalamus and hippocampus) in rat models of PMS irritability. They compared model rats to normal rats. They also tested how a traditional Chinese medicine called Baixiangdan affected these proteins. ## What they found In model rats, several proteins decreased: Ulip2, tubulin beta chain 15, alpha actin, IL-1 receptor accessory protein, hydrolase, albumin, and aldolase protein. Several proteins increased: kappa-B motif-binding phosphoprotein, M2 pyruvate kinase, panthenol-cytochrome C reductase core protein I, and calcium-binding protein. ## What it means for you The study identified new brain proteins that may be linked to premenstrual irritability. The traditional Chinese medicine Baixiangdan affected these protein patterns. However, finding that proteins changed does not tell us whether these changes cause irritability or are simply associated with it. These findings were only in rats. ## About the study Original title Profiling Proteins in the Hypothalamus and Hippocampus of a Rat Model of Premenstrual Syndrome Irritability Authors Qiao M, Sun P, Wang Y et al. Journal Neural plasticity Year 2017 Study design Lab study What was tested Baixiangdan (traditional Chinese medicine) Open access Yes Read the paper [doi.org/10.1155/2017/6537230](https://doi.org/10.1155/2017/6537230) Original abstract Premenstrual syndrome (PMS) refers to several physical and mental symptoms (such as irritability) commonly encountered in clinical gynaecology. The incidence of PMS has been increasing, attracting greater attention from medical fields. However, PMS pathogenesis remains unclear. This study employed two-dimensional gel electrophoresis (2DE) for proteomic map analysis of the hypothalamus and hippocampus of rat models of premenstrual syndrome (PMS) irritability. Matrix-assisted laser desorption/ionisation time of flight mass spectroscopy (MALDI-TOF-MS) was used to identify proteins possibly related with PMS irritability. Baixiangdan, a traditional Chinese medicine effective against PMS irritability, was used in the rat model to study putative target proteins of this medicine. The hypothalamus and hippocampus of each group modelling PMS displayed the following features: decreased expression of Ulip2, tubulin beta chain 15, α actin, and interleukin 1 receptor accessory protein; increased expression of kappa-B motif-binding phosphoprotein; decreased expression of hydrolase at the end of ubiquitin carboxy, albumin, and aldolase protein; and increased expression of M2 pyruvate kinase, panthenol-cytochrome C reductase core protein I, and calcium-binding protein. Contrasting with previous studies, the current study identified new proteins related to PMS irritability. Our findings contribute to understanding the pathogenesis of PMS irritability and could provide a reference point for further studies. Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Irritability and anger](https://niyora.com/research/topics/symptom-irritability-anger/)[Calcium](https://niyora.com/research/topics/treatment-calcium/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Non-randomised trial, 2021 Does a combination of exercise, ginger milk, and massage help premenstrual syndrome? Randomised trial, 2026 Does calcium and vitamin D supplementation reduce PMS symptoms? Randomised trial, 2025 Does the PMSoff supplement help PMS and PMDD symptoms? Review, 2015 What treatments work best for PMDD and PMS? Randomised trial, 2012 Does Vitex agnus castus work for PMS, and what dose is best? Randomised trial, 2010 What treatments work for premenstrual syndrome? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗