---
title: Can promegestone treat premenstrual syndrome? | Niyora
description: Possibly, but this study did not test it for PMS. The study tested promegestone for luteal insufficiency and found it more potent than dydrogesterone. The aut
url: https://niyora.com/research/papers/promegestone-a-new-progestin-1983/
---

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- Can promegestone treat premenstrual syndrome?

Non-randomised trial, 1983

# Can promegestone treat premenstrual syndrome?

Possibly, but this study did not test it for PMS. The study tested promegestone for luteal insufficiency and found it more potent than dydrogesterone. The authors suggest it may help with PMS, but only based on its properties, not actual testing.

 Early or limited evidence

Not specified in abstract

## What they did

A double-blind clinical trial tested promegestone (0.125 mg or 0.250 mg) against dydrogesterone (10 or 20 mg) for luteal insufficiency. The authors also discuss its potential use for hormone-dependent breast cancer and psychological symptoms of PMS and perimenopause.

## What they found

Promegestone showed significantly superior potency compared to dydrogesterone (p less than 0.001). The authors propose it may be useful for treating hormone-dependent breast cancer and the psychological disorders of PMS and perimenopause.

## What it means for you

Promegestone may be a more potent progestin than existing options, possibly including for PMS, but this study did not actually test it for PMS. This is from 1983 and presented as preliminary speculation. Newer research may provide clearer answers.

0.125-0.250 mg

Promegestone dose tested

p < 0.001

Significantly more potent than dydrogesterone

## About the study

Original title [Promegestone, a new progestin] Authors Raynaud JP, Ojasoo T Journal Journal de gynecologie, obstetrique et biologie de la reproduction Year 1983 Study design Non-randomised trial What was tested Promegestone 0.125-0.250 mg vs dydrogesterone 10-20 mg for luteal insufficiency Read the paper [https://pubmed.ncbi.nlm.nih.gov/6366037/](https://pubmed.ncbi.nlm.nih.gov/6366037/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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