---
title: Are prostaglandin hormone levels different in women with PMS?
description: Yes. Women with PMS have lower levels of one prostaglandin during the luteal phase and higher levels of several others at different times of the cycle.
url: https://niyora.com/research/papers/prostaglandins-and-premenstrual-syndrome-1992/
---

- [Niyora](https://niyora.com/)
- [Research](https://niyora.com/research/)
- [Library](https://niyora.com/research/library/)
- Are prostaglandin hormone levels different in women with PMS?

Case-control study, 1992

# Are prostaglandin hormone levels different in women with PMS?

Yes. Women with PMS have lower levels of one prostaglandin during the luteal phase and higher levels of several others at different times of the cycle.

 Early or limited evidence

20 women with PMS and 12 control women

## What they did

Researchers measured 5 prostaglandins (hormone-like signaling molecules) at several time points across 3 menstrual cycles in 20 women with PMS, and 1 cycle in 12 control women.

## What they found

In the late luteal phase, PMS women had significantly lower PGF2 alpha than controls. In the middle follicular and middle luteal phases, PMS women had significantly higher PGE. In the middle follicular phase, they had higher PGE2. In the middle and late luteal phases, they had higher TXB2. This suggests prostaglandin imbalance may contribute to PMS.

## What it means for you

Women with PMS may have an abnormal pattern of prostaglandin production throughout their cycle, which could contribute to symptoms. The study is small and controls were only tracked for 1 cycle instead of 3.

20

women with PMS

12

control women

5

prostaglandins measured

## About the study

Original title Prostaglandins and premenstrual syndrome Authors Koshikawa N, Tatsunuma T, Furuya K et al. Journal Prostaglandins, leukotrienes, and essential fatty acids Year 1992 Study design Case-control study Participants 20 Read the paper [doi.org/10.1016/0952-3278(92)90099-5](https://doi.org/10.1016/0952-3278(92)90099-5)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Cognition, concentration and memory](https://niyora.com/research/topics/symptom-cognition/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Systematic review, 2025

Does zinc supplementation help with PMS symptoms?

Systematic review, 2025

Does teaching adolescent girls about their menstrual cycle and health help reduce period pain and PMS?

Review, 2024

What are the most effective treatments for PMDD?

Systematic review, 2024

Do SSRI antidepressants help treat PMS and PMDD?

Cohort study, 2023

Are PMS symptoms linked to genetic factors for psychiatric disorders?

Cohort study, 2023

Is PMDD a valid medical diagnosis?

Ask AI about this page

Copy prompt

ChatGPT

↗

Claude

↗

Perplexity

↗

Google AI Mode

↗

Grok

↗