---
title: Is the PvuII-ESR1 gene variant linked to PMDD in South Indian women?
description: No. The study found no significant association between this specific gene variant and PMDD.
url: https://niyora.com/research/papers/pvuii-esr1-gene-polymorphism-in-premenstrual-dysphoric-disorder-in-south-indian-2024/
---

- [Niyora](https://niyora.com/)
- [Research](https://niyora.com/research/)
- [Library](https://niyora.com/research/library/)
- Is the PvuII-ESR1 gene variant linked to PMDD in South Indian women?

Survey study, 2024

# Is the PvuII-ESR1 gene variant linked to PMDD in South Indian women?

No. The study found no significant association between this specific gene variant and PMDD.

 Early or limited evidence

35 women with PMDD and 35 control women aged 18-45 in South India

## What they did

Genetic study in South India. Researchers recruited 35 women with PMDD and 35 control women aged 18-45 from clinic visitors. Participants completed a validated screening questionnaire and provided blood samples for genetic testing.

## What they found

The PvuII-ESR1 gene variant was present in both PMDD and control groups at similar rates. No significant association between the variant and PMDD. The screening questionnaire successfully distinguished women with PMDD from controls.

## What it means for you

This particular gene variant does not explain PMDD risk, at least in this population. The gene's overall role in PMDD remains unclear. Findings are limited to South Indian women and may not apply to other populations.

35

women with PMDD

35

control women

## About the study

Original title PvuII-ESR1 gene polymorphism in premenstrual dysphoric disorder in South Indian women Authors Charmanna SO, Srinivas A, Prashant A et al. Journal Indian journal of psychiatry Year 2024 Study design Survey study What was tested None (genetic analysis only) Open access Yes Read the paper [doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_461_24](https://doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_461_24)

## Topics

[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Cohort study, 2026

What genetic factors are linked to premenstrual symptoms?

Study, 2026

How do women with PMDD process emotions differently in their brains?

Systematic review, 2026

Can digital tools help diagnose PMDD?

Systematic review, 2026

Why do some women experience mood changes linked to their menstrual cycle?

Case-control study, 2026

Do women with PMS handle emotions differently at different times of the cycle?

Systematic review, 2025

How do cognition and behavior change across the menstrual cycle in people with PMDD?

Ask AI about this page

Copy prompt

ChatGPT

↗

Claude

↗

Perplexity

↗

Google AI Mode

↗

Grok

↗