---
title: Do women with PMS have different chemicals in their urine? | Niyora
description: Yes, women with PMS have lower levels of certain chemicals (prostaglandins and cyclic adenosine monophosphate) in their urine during the luteal phase.
url: https://niyora.com/research/papers/reduction-in-urinary-prostaglandin-excretion-in-the-premenstrual-syndrome-1993/
---

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- Do women with PMS have different chemicals in their urine?

Lab study, 1993

# Do women with PMS have different chemicals in their urine?

Yes, women with PMS have lower levels of certain chemicals (prostaglandins and cyclic adenosine monophosphate) in their urine during the luteal phase.

 Early or limited evidence

18 women with PMS and 18 healthy women

## What they did

Researchers collected urine samples during the luteal phase from 18 women with PMS and 18 healthy women. They measured levels of various chemicals that help control water and salt balance.

## What they found

Women with PMS had lower levels of prostaglandin E2, prostaglandin F2 alpha, and cyclic adenosine monophosphate. Sodium, aldosterone, and kallikrein levels were similar in both groups.

## What it means for you

This suggests the kidneys may handle water and other substances differently in women with PMS during the luteal phase, possibly explaining water retention. The study is small, so findings need confirmation in larger groups.

18

women with PMS

18

healthy women

## About the study

Original title Reduction in urinary prostaglandin excretion in the premenstrual syndrome Authors Piccoli A, Modena F, Calò L et al. Journal The Journal of reproductive medicine Year 1993 Study design Lab study Participants 18 Read the paper [https://pubmed.ncbi.nlm.nih.gov/8120851/](https://pubmed.ncbi.nlm.nih.gov/8120851/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)

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