---
title: Are PMDD and bipolar disorder connected? | Niyora
description: Yes. PMDD is more common in women with bipolar disorder than in the general population, and bipolar disorder is more common in women with PMDD. Between 10% an
url: https://niyora.com/research/papers/relationship-of-premenstrual-dysphoric-disorder-with-bipolar-disorder-a-2022/
---

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- Are PMDD and bipolar disorder connected?

Systematic review, 2022

# Are PMDD and bipolar disorder connected?

Yes. PMDD is more common in women with bipolar disorder than in the general population, and bipolar disorder is more common in women with PMDD. Between 10% and 15% of women with PMDD also have bipolar disorder, while 27% to 76% of women with bipolar disorder also have PMDD.

 Early or limited evidence

Women with both PMDD and bipolar disorder diagnoses from 5 research studies

## What they did

They searched five databases for studies published between 1987 and 2021 that included women with both PMDD and bipolar disorder diagnoses. They reviewed all studies that reported on both conditions together.

## What they found

Only 5 studies were available. PMDD is more common among women with bipolar disorder than in the general population, and bipolar disorder is more common among women with PMDD than in the general population. The proportion of people with PMDD and diagnosed with bipolar disorder ranged from 10% to 15%. The proportion of people with bipolar disorder who received a PMDD diagnosis ranged from 27% to 76%.

## What it means for you

These two conditions seem to be linked, but we don't have much research yet. The main limitations are that only 5 studies were available and they didn't use prospective monitoring of symptoms, which is the most reliable way to confirm PMDD.

5

studies included in review

10-15%

of women with PMDD also have bipolar disorder

27-76%

of women with bipolar disorder have PMDD

## About the study

Original title Relationship of Premenstrual Dysphoric Disorder With Bipolar Disorder: A Systematic Review Authors Sharma V, Mazmanian D, Eccles H Journal The Journal of clinical psychiatry Year 2022 Study design Systematic review Read the paper [doi.org/10.4088/jcp.22r14416](https://doi.org/10.4088/jcp.22r14416)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Premenstrual exacerbation (PME)](https://niyora.com/research/topics/condition-pme/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Bipolar disorder](https://niyora.com/research/topics/comorbidity-bipolar/)[Relationships and partners](https://niyora.com/research/topics/life-area-relationships/)

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Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Survey study, 2006

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Study, 2026

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Survey study, 2026

What is the true rate of PMDD, and does it worsen mental health conditions?

Cohort study, 2023

Does the menstrual cycle affect how often women have suicidal thoughts?

Guideline, 2006

What is the best treatment for PMDD and severe PMS?

Review, 2025

How does the menstrual cycle affect psychiatric symptoms like depression and anxiety?

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