--- title: Does the combination of sumatriptan and naproxen sodium reduce menstrual symptoms and migraine? description: Yes. The combination was better than placebo for tiredness, irritability, bloating, abdominal pain, and back pain, as well as migraine. However, women with se url: https://niyora.com/research/papers/relief-of-menstrual-symptoms-and-migraine-with-a-single-tablet-formulation-of-2014/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does the combination of sumatriptan and naproxen sodium reduce menstrual symptoms and migraine? Randomised trial, 2014 # Does the combination of sumatriptan and naproxen sodium reduce menstrual symptoms and migraine? Yes. The combination was better than placebo for tiredness, irritability, bloating, abdominal pain, and back pain, as well as migraine. However, women with severe period pain responded less well to migraine treatment. Strong study design 621 women with menstrual migraine and period pain ## What they did Two similar RCTs with a total of 621 women who had menstrual migraines and period pain. When they got a migraine, women took either sumatriptan-naproxen or placebo. Researchers tracked relief of headache, bloating, fatigue, irritability, abdominal pain, and back pain at multiple time points: 30 minutes, 1 hour, 2 hours, 4 hours, and 4-24 hours. ## What they found Sumatriptan-naproxen was better than placebo for tiredness, irritability, and belly pain at 2, 4, and 4-24 hours. It also helped back pain at 4 and 4-24 hours and bloating at 4-24 hours. The more moderate to severe period pain symptoms a woman had, the less likely she was to respond to migraine treatment. ## What it means for you This combination medication may help both menstrual migraine and the period symptoms that come with it. The finding about severe period pain reducing migraine treatment response is important. The study included 621 women, which is large, but only women who had both migraine and period pain, so results may not apply to all women with PMS. 621 women studied 2 replicate RCTs pooled together 4-24 hours window for symptom relief ## About the study Original title Relief of menstrual symptoms and migraine with a single-tablet formulation of sumatriptan and naproxen sodium Authors Martin VT, Ballard J, Diamond MP et al. Journal Journal of women's health (2002) Year 2014 Study design Randomised trial What was tested Sumatriptan and naproxen sodium combination taken when migraine started Open access Yes Read the paper [doi.org/10.1089/jwh.2013.4577](https://doi.org/10.1089/jwh.2013.4577) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Dysmenorrhea and period pain](https://niyora.com/research/topics/condition-dysmenorrhea/)[Irritability and anger](https://niyora.com/research/topics/symptom-irritability-anger/)[Fatigue and energy](https://niyora.com/research/topics/symptom-fatigue/)[Bloating, breast tenderness and physical symptoms](https://niyora.com/research/topics/symptom-physical-symptoms/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Diuretics and other drugs](https://niyora.com/research/topics/treatment-diuretics-other-drugs/)[Migraine](https://niyora.com/research/topics/comorbidity-migraine/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Cohort study, 2006 How should severe period pain in teenagers be treated? Survey study, 1982 How common are premenstrual symptoms in American women, and what factors affect them? Non-randomised trial, 2023 Does mefenamic acid help relieve PMS symptoms? Survey study, 2023 Does PMS affect school performance and relationships in female medical students? Non-randomised trial, 1983 Do drugs that block prostaglandins help PMS? Systematic review, 2021 Does damask rose help reduce menstrual pain, headache, fatigue, anxiety, and bloating? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗