--- title: Do women with depression or bipolar disorder experience premenstrual mood symptoms? description: 67.7% of women with major depression or bipolar disorder reported premenstrual mood symptoms, significantly more than women without mood disorders. The rates url: https://niyora.com/research/papers/reproductive-cycle-associated-mood-symptoms-in-women-with-major-depression-and-2007/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Do women with depression or bipolar disorder experience premenstrual mood symptoms? Cohort study, 2007 # Do women with depression or bipolar disorder experience premenstrual mood symptoms? 67.7% of women with major depression or bipolar disorder reported premenstrual mood symptoms, significantly more than women without mood disorders. The rates were similar between the two diagnoses. Early or limited evidence 2524 women with major depression or bipolar I disorder ## What they did 2524 women with major depression or bipolar I disorder answered standardized questions about mood symptoms before menstruation, within a month of childbirth, and during perimenopause. Lifetime rates for each symptom type were calculated and odds ratios determined to see if different types of symptoms correlated. ## What they found Of 2524 women with mood disorders, 67.7% reported premenstrual symptoms. Of those at risk, 20.9% reported postpartum mood changes and 26.4% reported perimenopausal mood changes. Rates did not differ between women with major depression and bipolar I disorder but were significantly different from women who were never ill. In major depression, symptoms were significantly correlated with odds ratios from 1.66 to 1.82. These correlations were not found in bipolar disorder. ## What it means for you Women with depression often experience mood changes linked to reproductive events across their lifespan, while this pattern differs in bipolar disorder, suggesting different underlying biology. The main limitation is that women reported past symptoms from memory, which can be inaccurate. This was a secondary analysis of data collected for other purposes. 2524 women with mood disorders 67.7% reported premenstrual mood symptoms 1.66-1.82 odds ratios for symptom correlation in depression ## About the study Original title Reproductive cycle-associated mood symptoms in women with major depression and bipolar disorder Authors Payne JL, Roy PS, Murphy-Eberenz K et al. Journal Journal of affective disorders Year 2007 Study design Cohort study Participants 2,524 What was tested None (observational retrospective analysis) Open access Yes Read the paper [doi.org/10.1016/j.jad.2006.08.013](https://doi.org/10.1016/j.jad.2006.08.013) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Bipolar disorder](https://niyora.com/research/topics/comorbidity-bipolar/)[Major depressive disorder](https://niyora.com/research/topics/comorbidity-major-depression/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/)[Pregnancy and postpartum](https://niyora.com/research/topics/comorbidity-postpartum/)[Work and productivity](https://niyora.com/research/topics/life-area-work/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Survey study, 2025 Do women with bipolar disorder who had PMS or postpartum depression have worse mood problems during menopause? Review, 2012 Is depression linked to hormonal changes during the menstrual cycle, pregnancy, and menopause? Review, 2011 Can estrogen hormones treat depression linked to the menstrual cycle? Randomised trial, 2001 Do changing reproductive hormones disrupt the body's internal clock and cause mood disorders? Systematic review, 2026 Why do some women experience mood changes linked to their menstrual cycle? Review, 1992 Is PMS really caused by hormones? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗