---
title: Does bromocriptine or pyridoxine help reduce PMS symptoms? | Niyora
description: Both bromocriptine and pyridoxine significantly reduced PMS symptoms over 3 months. Pyridoxine showed a higher response rate with fewer side effects.
url: https://niyora.com/research/papers/role-of-bromocriptine-and-pyridoxine-in-premenstrual-tension-syndrome-2007/
---

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- Does bromocriptine or pyridoxine help reduce PMS symptoms?

Randomised trial, 2007

# Does bromocriptine or pyridoxine help reduce PMS symptoms?

Both bromocriptine and pyridoxine significantly reduced PMS symptoms over 3 months. Pyridoxine showed a higher response rate with fewer side effects.

 Moderate study design

60 women aged 20-45 with PMS (20 per treatment group)

## What they did

RCT comparing bromocriptine (2.5 mg twice daily), pyridoxine (100 mg/day), and placebo (ferrous sulphate 100 mg) in 60 women aged 20-45 with PMS. Women were followed monthly for 3 months and symptom scores were recorded before and after treatment.

## What they found

The placebo group showed no significant change. Both bromocriptine and pyridoxine significantly reduced mean premenstrual symptom scores. Pyridoxine showed a significantly higher response rate and lower rate of side effects compared to bromocriptine.

## What it means for you

Both drugs can reduce PMS symptoms, but pyridoxine appears safer and more effective. The main limit is the small sample size of 20 women per treatment group, so these results may not apply to larger or more diverse populations.

60

women total

3

months of treatment

100 mg/day

pyridoxine dose

## About the study

Original title Role of bromocriptine and pyridoxine in premenstrual tension syndrome Authors Sharma P, Kulshreshtha S, Singh GM et al. Journal Indian journal of physiology and pharmacology Year 2007 Study design Randomised trial Participants 20 What was tested Bromocriptine 2.5 mg twice daily, pyridoxine 100 mg/day, or placebo (ferrous sulphate 100 mg daily) for 3 months Read the paper [https://pubmed.ncbi.nlm.nih.gov/18476391/](https://pubmed.ncbi.nlm.nih.gov/18476391/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Vitamin B6](https://niyora.com/research/topics/treatment-vitamin-b6/)[Diuretics and other drugs](https://niyora.com/research/topics/treatment-diuretics-other-drugs/)

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