---
title: Does danazol, a synthetic steroid, relieve PMS symptoms? | Niyora
description: In this small case study of 21 women, danazol relieved PMS symptoms in up to 85% of patients when combined with other treatment approaches. It worked best for
url: https://niyora.com/research/papers/role-of-danazol-in-relieving-the-premenstrual-syndrome-1990/
---

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- Does danazol, a synthetic steroid, relieve PMS symptoms?

Review, 1990

# Does danazol, a synthetic steroid, relieve PMS symptoms?

In this small case study of 21 women, danazol relieved PMS symptoms in up to 85% of patients when combined with other treatment approaches. It worked best for women whose main symptom was breast pain.

 Early or limited evidence

21 women with PMS

## What they did

Case series: the author treated 21 women with PMS using danazol (a synthetic steroid called Danocrine) plus non-medication treatment options

## What they found

Danazol relieved PMS symptoms in up to 85% of the 21 patients. Women whose PMS was characterized mainly by breast pain (mastalgia) responded most favorably to treatment. Danazol is not recommended for women whose main symptoms are depression or anxiety.

## What it means for you

Danazol appears to help many women with PMS, especially those with breast pain. However, this was a very small study with no comparison group, so it is not strong evidence.

21

women treated with danazol

up to 85%

showed symptom relief

approx 90%

of women experience some PMS

## About the study

Original title Role of danazol in relieving the premenstrual syndrome Authors Derzko CM Journal The Journal of reproductive medicine Year 1990 Study design Review What was tested Danazol (synthetic steroid) combined with non-medication approaches Read the paper [https://pubmed.ncbi.nlm.nih.gov/2404119/](https://pubmed.ncbi.nlm.nih.gov/2404119/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)[Vitamin B6](https://niyora.com/research/topics/treatment-vitamin-b6/)

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