--- title: Do women with both seasonal affective disorder and PMDD share genetic risk factors? description: Yes. Women with both SAD and PMDD were significantly more likely to have a specific genetic variation and family history of mood disorders, suggesting they sh url: https://niyora.com/research/papers/role-of-family-history-and-5-httlpr-polymorphism-in-female-seasonal-affective-2002/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Do women with both seasonal affective disorder and PMDD share genetic risk factors? Case-control study, 2002 # Do women with both seasonal affective disorder and PMDD share genetic risk factors? Yes. Women with both SAD and PMDD were significantly more likely to have a specific genetic variation and family history of mood disorders, suggesting they share genetic vulnerability to both conditions. Early or limited evidence 44 women with both SAD and PMDD, and 43 women with SAD without PMDD ## What they did Case-control study genotyping 44 women with both SAD and PMDD and 43 women with SAD alone for a serotonin gene variant (5-HTTLPR). Researchers also assessed family history of affective disorders. ## What they found An association was found between PMDD and family history of affective disorders (P=0.0029) and between PMDD and the 5-HTTLPR long/short allele-heterozygosity genetic variation (P=0.033). Relatives of women with both SAD and PMDD had higher rates of affective disorders. ## What it means for you Some women may be genetically predisposed to both seasonal depression and PMDD, possibly through serotonin system dysfunction. This is a small study that needs confirmation in larger groups. 44 women with SAD and PMDD 43 women with SAD alone P=0.0029 family history association ## About the study Original title Role of family history and 5-HTTLPR polymorphism in female seasonal affective disorder patients with and without premenstrual dysphoric disorder Authors Praschak-Rieder N, Willeit M, Winkler D et al. Journal European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology Year 2002 Study design Case-control study Participants 43 What was tested None; genetic comparison study Read the paper [doi.org/10.1016/s0924-977x(01)00146-8](https://doi.org/10.1016/s0924-977x(01)00146-8) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Athletes and sport](https://niyora.com/research/topics/life-area-athletes/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Systematic review, 2025 Are PMS and PMDD more common in highly trained female athletes than in women who don't train intensively? Systematic review, 2023 How common are menstrual cycle problems and PMS or PMDD in female athletes? Randomised trial, 2024 Does a banana drink with egg white reduce PMDD symptoms and improve mood? Case-control study, 2020 How does competitive sports affect PMS, PMDD, and menstrual disorders in young female athletes? Survey study, 2019 What lifestyle and sleep habits are linked to PMS in teenage girls? Cohort study, 2019 Do young female athletes have more menstrual problems and PMS than non-athletes? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗