--- title: Do herbal medicines and nutritional supplements help relieve PMS symptoms? description: Yes. A review of 25 high-quality studies with 1949 participants found that herbs and supplements with antioxidant and anti-inflammatory properties can effecti url: https://niyora.com/research/papers/role-of-inflammation-oxidative-stress-and-mitochondrial-changes-in-premenstrual-2022/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Do herbal medicines and nutritional supplements help relieve PMS symptoms? Randomised trial, 2022 # Do herbal medicines and nutritional supplements help relieve PMS symptoms? Yes. A review of 25 high-quality studies with 1949 participants found that herbs and supplements with antioxidant and anti-inflammatory properties can effectively relieve PMS symptoms. More research is needed to confirm how well they work. Strong study design 1949 participants across 25 studies with PMS ## What they did Systematic review of randomized controlled trials published between 1990 and 2022. Researchers searched multiple databases and evaluated the quality of studies using a standardized scale. They included 25 randomized controlled trials with a total of 1949 participants. ## What they found The review identified 25 high-quality randomized controlled studies. Many bioactive compounds found in herbs and supplements, such as curcumin, allicin, anethole, thymoquinone, cyanidin 3-glucoside, and gamma-linoleic acid, have antioxidant and anti-inflammatory properties. Traditional Unani herbal medicine and nutritional supplements can effectively relieve PMS symptoms. ## What it means for you Several herbs and supplements show promise for treating PMS based on review of existing research. The main limit is that more rigorous research is needed to fully understand how well these treatments work. 25 randomized controlled studies reviewed 1949 total participants ## About the study Original title Role of Inflammation, Oxidative Stress, and Mitochondrial Changes in Premenstrual Psychosomatic Behavioral Symptoms with Anti-Inflammatory, Antioxidant Herbs, and Nutritional Supplements Authors Sultana A, Rahman K, Heyat MBB et al. Journal Oxidative medicine and cellular longevity Year 2022 Study design Randomised trial What was tested Herbal medicine and nutritional supplements with antioxidant and anti-inflammatory properties Open access Yes Read the paper [doi.org/10.1155/2022/3599246](https://doi.org/10.1155/2022/3599246) Original abstract Premenstrual syndrome (PMS) significantly lowers the quality of life and impairs personal and social relationships in reproductive-age women. Some recommendations are that inappropriate oxidative stress and inflammatory response are involved in PMS. Various nutritional supplements and herbs showed neuro-psycho-pharmacological activity with antioxidant and anti-inflammatory properties. This study aims to determine the systematic review of randomized controlled trials (RCTs) of herbal medicine and nutritional supplements in PMS. We also comprehensively highlighted the role of oxidative stress, inflammation, and mitochondrial changes on PMS with the application of computational intelligence. We used PRISMA and research question-based techniques to collect the data for evaluation of our study on different databases such as Scopus, PubMed, and PROSPERO from 1990 to 2022. The methodological quality of the published study was assessed by the modified Jadad scale. In addition, we used network visualization and word cloud techniques to find the closest terms of the study based on previous publications. While we also used computational intelligence techniques to give the idea for the classification of experimental data from PMS. We found 25 randomized controlled studies with 1949 participants (mean ± SD: 77.96 ± 22.753) using the PRISMA technique, and all were high-quality studies. We also extracted the closest terms related to our study using network visualization techniques. This work has revealed the future direction and research gap on the role of oxidative stress and inflammation in PMS. In vitro and in vivo studies showed that bioactive molecules such as curcumin, allicin, anethole, thymoquinone, cyanidin 3-glucoside, gamma-linoleic acid, and various molecules not only have antioxidant and anti-inflammatory properties but also other various activities such as GABA-A receptor agonist, serotonergic, antidepressant, sedative, and analgesic. Traditional Unani Herbal medicine and nutritional supplements can effectively relieve PMS symptoms as they possess many bioactive molecules that are pharmacologically proven for the aforementioned properties. Hence, these biomolecules might influence a complex physical and psychological disease process like PMS. However, more rigorous research studies are recommended for in-depth knowledge of the efficacy of bioactive molecules on premenstrual syndrome in clinical trials. Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Stress](https://niyora.com/research/topics/symptom-stress/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Neurosteroids (allopregnanolone)](https://niyora.com/research/topics/treatment-neurosteroids/)[Diet and nutrition](https://niyora.com/research/topics/treatment-diet/)[Curcumin and turmeric](https://niyora.com/research/topics/treatment-curcumin/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Review, 2023 Can herbs and supplements help with PMS symptoms? Non-randomised trial, 2020 What treatments help premenstrual syndrome? Randomised trial, 2010 What treatments work for premenstrual syndrome? Systematic review, 2007 What treatments work for premenstrual syndrome? Non-randomised trial, 2025 What treatments help PMS and PMDD? Case report, 2026 Does eating a special rice porridge diet help PMS symptoms? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗