---
title: Are SSRIs like fluoxetine effective treatments for PMDD? | Niyora
description: Fluoxetine is FDA-approved for PMDD, but it only works for a small subset of women and the treatment benefits are limited.
url: https://niyora.com/research/papers/selective-serotonin-reuptake-inhibitors-and-treatment-of-premenstrual-dysphoric-2002/
---

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- Are SSRIs like fluoxetine effective treatments for PMDD?

Review, 2002

# Are SSRIs like fluoxetine effective treatments for PMDD?

Fluoxetine is FDA-approved for PMDD, but it only works for a small subset of women and the treatment benefits are limited.

 Early or limited evidence

Women with PMDD

## What they did

A literature review of research on SSRIs for treating PMDD, focusing on recent findings and the FDA approval of fluoxetine.

## What they found

SSRIs show effectiveness in treating PMDD. The FDA approved fluoxetine specifically for PMDD treatment, but this approval applies to a small subset of women with premenstrual complaints, and treatment efficacy is limited.

## What it means for you

While SSRIs can help some women with PMDD, they do not work for most women. Advanced practice nurses need to understand that PMDD diagnosis and treatment are still debated among professionals.

Small subset

of women eligible

## About the study

Original title Selective serotonin reuptake inhibitors and treatment of premenstrual dysphoric disorder Authors Finfgeld DL Journal Perspectives in psychiatric care Year 2002 Study design Review What was tested SSRIs, particularly fluoxetine Read the paper [doi.org/10.1111/j.1744-6163.2002.tb00657.x](https://doi.org/10.1111/j.1744-6163.2002.tb00657.x)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Systematic review, 2024

What are the best treatments for PMDD and PMS?

Review, 2024

What are the most effective treatments for PMDD?

Systematic review, 2024

Do SSRI antidepressants help treat PMS and PMDD?

Randomised trial, 2023

Does taking sertraline when PMDD symptoms start improve how well women function?

Guideline, 2023

How are GnRH agonists used to treat PMDD that doesn't respond to standard medications?

Review, 2022

What causes severe PMS and what treatments work?

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