--- title: Are low calcium and other minerals related to PMS symptoms? | Niyora description: Yes, very low calcium is extremely common in women with PMS, and weak associations were found between low sodium or magnesium and some PMS symptoms like anxie url: https://niyora.com/research/papers/seric-ion-level-and-its-relationship-with-the-symptoms-of-premenstrual-syndrome-2013/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Are low calcium and other minerals related to PMS symptoms? Randomised trial, 2013 # Are low calcium and other minerals related to PMS symptoms? Yes, very low calcium is extremely common in women with PMS, and weak associations were found between low sodium or magnesium and some PMS symptoms like anxiety and depression. However, this study only shows association, not proof of causation. Early or limited evidence 93 young women ## What they did Observational study (no intervention). 93 young women were monitored for 3 months. Daily symptoms were recorded, and blood tests measured sodium, potassium, calcium, magnesium, hemoglobin and hematocrit during the luteal phase. ## What they found Anxiety, depression, swelling and breast pain were most severe during the menstrual phase. About 83% of women had lower than normal calcium levels. About 24% had anemia. Weak associations were found between low sodium and anxiety, and between low magnesium and depression and nausea. ## What it means for you Low calcium is very common in women with PMS, but we don't know if it causes PMS or is just associated with it. This is an observational study with no control group, so stronger evidence is needed. Anemia also appears common and may contribute to symptoms. 3 months Monitoring period 83.09% Low calcium prevalence 24% Anemia prevalence ## About the study Original title Seric ion level and its relationship with the symptoms of premenstrual syndrome in young women Authors dos Santos LA, de Azeredo VB, Eloy Chaves Barbosa D et al. Journal Nutricion hospitalaria Year 2013 Study design Randomised trial What was tested None - observational study only Read the paper [doi.org/10.3305/nutr hosp.v28in06.6648](https://doi.org/10.3305/nutr hosp.v28in06.6648) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Diet and nutrition](https://niyora.com/research/topics/treatment-diet/)[Calcium](https://niyora.com/research/topics/treatment-calcium/)[Magnesium](https://niyora.com/research/topics/treatment-magnesium/)[Relationships and partners](https://niyora.com/research/topics/life-area-relationships/)[Adolescents and young people](https://niyora.com/research/topics/life-area-adolescents/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Survey study, 2009 Does nutrition affect premenstrual syndrome in teenage girls? Survey study, 2026 What dietary, lifestyle, and psychological factors are associated with PMS in young women? Review, 2023 Can herbs and supplements help with PMS symptoms? Case-control study, 2020 Is diet quality lower in teenagers with PMS? Survey study, 2014 Are depression and anxiety linked to period pain in teenage girls? Survey study, 2026 Does PMS affect how well young women sleep? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗