---
title: Are specific genetic variations linked to PMDD? | Niyora
description: No. This study found no significant association between eight common genetic variations in serotonin pathways and PMDD, suggesting these particular genetic va
url: https://niyora.com/research/papers/serotonin-transporter-tryptophan-hydroxylase-and-monoamine-oxidase-a-gene-2006/
---

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- Are specific genetic variations linked to PMDD?

Cohort study, 2006

# Are specific genetic variations linked to PMDD?

No. This study found no significant association between eight common genetic variations in serotonin pathways and PMDD, suggesting these particular genetic variations are not major contributors to PMDD.

 Moderate study design

53 women with clinically diagnosed PMDD (mean age 37.7 years) and 52 control women (mean age 36.2 years)

## What they did

Researchers studied 53 women with PMDD (mean age 37.7 years) and 52 healthy control women (mean age 36.2 years). They tested them for eight genetic variations in genes that control serotonin, including genes for serotonin transporter, tryptophan hydroxylase, and monoamine oxidase A. They compared the frequency of genetic variants between the two groups.

## What they found

None of the eight genetic variants showed any significant difference between women with PMDD and control women. No significant allelic distribution profiles were found in either group.

## What it means for you

These particular serotonin-related genetic variations do not appear to play a major role in causing PMDD. This does not rule out other genes or other ways that biology might contribute to PMDD. Larger studies or studies of different genetic variants might find different results.

53

Women with PMDD

52

Control women

8

Genetic variations tested

## About the study

Original title Serotonin transporter, tryptophan hydroxylase, and monoamine oxidase A gene polymorphisms in premenstrual dysphoric disorder Authors Magnay JL, Ismail KM, Chapman G et al. Journal American journal of obstetrics and gynecology Year 2006 Study design Cohort study Participants 53 What was tested None Read the paper [doi.org/10.1016/j.ajog.2006.06.087](https://doi.org/10.1016/j.ajog.2006.06.087)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Athletes and sport](https://niyora.com/research/topics/life-area-athletes/)

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