---
title: Do serotonin reuptake inhibitors help premenstrual dysphoria?
description: Yes, very effectively. These medications work rapidly and are more effective than non-serotonergic antidepressants.
url: https://niyora.com/research/papers/serotonin-uptake-inhibitors-provide-rapid-relief-from-premenstrual-dysphoria-new-2001/
---

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- Do serotonin reuptake inhibitors help premenstrual dysphoria?

Review, 2001

# Do serotonin reuptake inhibitors help premenstrual dysphoria?

Yes, very effectively. These medications work rapidly and are more effective than non-serotonergic antidepressants.

 Moderate study design

Women with premenstrual dysphoria, which affects 5 to 10 percent of all women

## What they did

Literature review examining the effects of serotonin reuptake inhibitors and other antidepressants on premenstrual dysphoria.

## What they found

Serotonin reuptake inhibitors very effectively reduce symptoms of premenstrual dysphoria with rapid onset of action. Non-serotonergic antidepressants do not reduce symptoms. The cardinal symptom is irritability, which appears between ovulation and menstruation and disappears within a few days of menstruation.

## What it means for you

Serotonin reuptake inhibitors can be used only during the luteal phase rather than continuously, which is practical for treatment. This is a literature review, so findings come from summarizing other studies rather than new research.

5-10%

Women affected by premenstrual dysphoria

## About the study

Original title [Serotonin uptake inhibitors provide rapid relief from premenstrual dysphoria. New findings shed light on how serotonin modulates sex hormone-related behavior] Authors Eriksson E, Andersch B, Ho HP et al. Journal Lakartidningen Year 2001 Study design Review What was tested Serotonin reuptake inhibitors Read the paper [https://pubmed.ncbi.nlm.nih.gov/11571794/](https://pubmed.ncbi.nlm.nih.gov/11571794/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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