---
title: Are vitamin D and magnesium levels lower in women with PMS than in women without it?
description: Yes. Women with PMS had much lower vitamin D and somewhat lower magnesium levels than women without PMS, and the two measurements were positively linked.
url: https://niyora.com/research/papers/serum-magnesium-and-25-hydroxy-cholecalciferol-in-premenstrual-syndrome-during-2017/
---

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- Are vitamin D and magnesium levels lower in women with PMS than in women without it?

Survey study, 2017

# Are vitamin D and magnesium levels lower in women with PMS than in women without it?

Yes. Women with PMS had much lower vitamin D and somewhat lower magnesium levels than women without PMS, and the two measurements were positively linked.

 Early or limited evidence

85 unmarried women aged 18 to 28 in Pakistan, divided into PMS cases and healthy controls

## What they did

Comparative study of 85 unmarried women aged 18 to 28, split into a PMS group and a control group. During the luteal phase, researchers measured serum vitamin D (25-hydroxy cholecalciferol) and serum magnesium in both groups.

## What they found

Vitamin D was much lower in PMS cases (14.88 ±2.39) than controls (26.20 ±4.30), p=0.0001, with some PMS cases as low as 8 ng/dl. Magnesium was also lower in PMS cases (1.72 ±0.31) than controls (1.84 ±0.12), p=0.02. Vitamin D and magnesium levels were positively correlated (r=0.24, p=0.02).

## What it means for you

Low vitamin D and low magnesium may both play a role in PMS, and the two seem connected. The study only compared two groups at one hospital and was fairly small, so it cannot prove that low levels cause PMS.

p=0.0001

Vitamin D difference

p=0.02

Magnesium difference

r=0.24

Vit D-Mg correlation

## About the study

Original title Serum Magnesium and 25-Hydroxy Cholecalciferol in Premenstrual Syndrome during Luteal Phase Journal Journal of Liaquat University of Medical & Health Sciences Year 2017 Study design Survey study Participants 85 What was tested No treatment tested; compared serum vitamin D and magnesium between PMS cases and controls Open access Yes Read the paper [doi.org/10.22442/jlumhs.171640535](https://doi.org/10.22442/jlumhs.171640535)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Oral contraceptives and drospirenone](https://niyora.com/research/topics/treatment-hormonal-contraceptives/)[Magnesium](https://niyora.com/research/topics/treatment-magnesium/)[Vitamin D](https://niyora.com/research/topics/treatment-vitamin-d/)

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