---
title: Does progesterone help asthma that gets worse before your period?
description: Yes. Three patients with severe asthma that worsened each month and hadn't responded to other treatments had the monthly breathing problems stop after startin
url: https://niyora.com/research/papers/severe-premenstrual-exacerbations-of-asthma-effect-of-intramuscular-progesterone-1988/
---

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- Does progesterone help asthma that gets worse before your period?

Case report, 1988

# Does progesterone help asthma that gets worse before your period?

Yes. Three patients with severe asthma that worsened each month and hadn't responded to other treatments had the monthly breathing problems stop after starting progesterone injections.

 Early or limited evidence

3 patients with severe asthma that worsens before their period

## What they did

Case report of three patients with severe asthma that got much worse before their period. They added progesterone injections to their treatment. Two patients got 100 mg daily, one got 600 mg twice a week.

## What they found

The monthly drops in peak flow (breathing ability) stopped in all three patients. All three had their steroid pill doses reduced.

## What it means for you

Progesterone injections may help severe asthma that worsens each month, but this finding is based on only three patients. Much larger studies are needed to know if this works more broadly.

3

patients treated

100 mg

progesterone daily dose

600 mg

progesterone dose twice weekly

## About the study

Original title Severe premenstrual exacerbations of asthma: effect of intramuscular progesterone Authors Beynon HL, Garbett ND, Barnes PJ Journal Lancet (London, England) Year 1988 Study design Case report Participants 100 What was tested Intramuscular progesterone (100 mg daily or 600 mg twice weekly) Read the paper [doi.org/10.1016/s0140-6736(88)92837-1](https://doi.org/10.1016/s0140-6736(88)92837-1)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual exacerbation (PME)](https://niyora.com/research/topics/condition-pme/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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Review, 2012

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Randomised trial, 2000

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