---
title: Does rimegepant prevent migraines around your period? | Niyora
description: Rimegepant prevented perimenstrual migraines in 85% of cycles with no side effects in this small study of 5 women, but we need larger studies to be confident
url: https://niyora.com/research/papers/short-term-prevention-of-perimenstrual-migraine-with-rimegepant-2025/
---

- [Niyora](https://niyora.com/)
- [Research](https://niyora.com/research/)
- [Library](https://niyora.com/research/library/)
- Does rimegepant prevent migraines around your period?

Randomised trial, 2025

# Does rimegepant prevent migraines around your period?

Rimegepant prevented perimenstrual migraines in 85% of cycles with no side effects in this small study of 5 women, but we need larger studies to be confident in these results.

 Early or limited evidence

5 women aged 22-42 with episodic migraine and regular menstrual cycles

## What they did

Case series of 5 women aged 22-42 with episodic migraine and regular menstrual cycles. They took rimegepant 75 mg every other day starting 2 days before menstruation and continuing 2 days after menstruation. Patients kept daily headache diaries and were followed for 3-4 cycles.

## What they found

Rimegepant prevented perimenstrual attacks in 17 of 20 cycles (85%) with no treatment-related side effects. However, only 1 patient (20%) had sustained reduction in overall monthly migraine days. Three patients (60%) experienced delayed migraine onset 3-7 days after menstruation rather than complete prevention.

## What it means for you

Rimegepant appears promising for preventing migraines around your period and was well tolerated. However, this was a very small case series with only 5 women and no control group. Some women's migraines were delayed rather than prevented. Much larger randomized controlled trials are needed to confirm these findings.

5

women in study

85%

of cycles with prevented attacks

60%

experienced delayed migraine

## About the study

Original title Short-term prevention of perimenstrual migraine with rimegepant Authors Frank F, Schiefecker A, Kaltseis K et al. Journal The journal of headache and pain Year 2025 Study design Randomised trial What was tested Rimegepant 75 mg orally disintegrating tablet every other day for 2 days before and 2 days after menstruation Open access Yes Read the paper [doi.org/10.1186/s10194-025-02185-y](https://doi.org/10.1186/s10194-025-02185-y)

## Topics

[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Diuretics and other drugs](https://niyora.com/research/topics/treatment-diuretics-other-drugs/)[Migraine](https://niyora.com/research/topics/comorbidity-migraine/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Randomised trial, 2014

Does the combination of sumatriptan and naproxen sodium reduce menstrual symptoms and migraine?

Randomised trial, 2011

Does sumatriptan-naproxen help women with period migraines and period pain function better?

Randomised trial, 2010

Does a sumatriptan and naproxen combination help menstrual migraine and period pain?

Survey study, 2010

What treatments work for migraine during the menstrual cycle?

Case report, 2010

Do Meniere disease symptoms get worse before a woman's period?

Review, 2009

What medications work for migraines around the menstrual period?

Ask AI about this page

Copy prompt

ChatGPT

↗

Claude

↗

Perplexity

↗

Google AI Mode

↗

Grok

↗