---
title: How should PMDD be treated with antidepressants? | Niyora
description: SSRIs and venlafaxine are effective for PMDD at normal doses taken either every day or intermittently during the luteal phase. Both dosing schedules work at n
url: https://niyora.com/research/papers/special-issues-in-the-management-of-depression-in-women-2004/
---

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- How should PMDD be treated with antidepressants?

Review, 2004

# How should PMDD be treated with antidepressants?

SSRIs and venlafaxine are effective for PMDD at normal doses taken either every day or intermittently during the luteal phase. Both dosing schedules work at normal doses but low doses do not.

 Moderate study design

Women with PMDD and depression-related conditions specific to women.

## What they did

This is a review of medical research on depression in women and conditions specific to women, including PMDD.

## What they found

Antidepressants (SSRIs and venlafaxine) demonstrate efficacy in PMDD. Both continuous daily dosing and intermittent dosing work at usual dosages but not at low dosages.

## What it means for you

For women with PMDD, antidepressants at normal doses work whether taken continuously or intermittently. A limitation is that this is a review of existing research rather than a new study.

## About the study

Original title Special issues in the management of depression in women Authors MacQueen G, Chokka P Journal Canadian journal of psychiatry. Revue canadienne de psychiatrie Year 2004 Study design Review What was tested SSRIs and venlafaxine (antidepressant medications) Read the paper [https://pubmed.ncbi.nlm.nih.gov/15147034/](https://pubmed.ncbi.nlm.nih.gov/15147034/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Major depressive disorder](https://niyora.com/research/topics/comorbidity-major-depression/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/)[Pregnancy and postpartum](https://niyora.com/research/topics/comorbidity-postpartum/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Review, 2012

Is depression linked to hormonal changes during the menstrual cycle, pregnancy, and menopause?

Survey study, 2002

What treatments work for depression linked to the menstrual cycle and PMDD?

Guideline, 2001

What is the best treatment for PMDD and depression in women?

Study, 2004

Did SSRIs change what people thought of as depression in women?

Review, 2002

Are women more likely to get depression, especially due to hormonal changes?

Randomised trial, 2001

Do changing reproductive hormones disrupt the body's internal clock and cause mood disorders?

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