---
title: Does St. John's wort help treat PMDD? | Niyora
description: In this one case, yes. A woman with PMDD who couldn't tolerate a common antidepressant improved significantly on St. John's wort over at least five months.
url: https://niyora.com/research/papers/st-john-s-wort-hypericum-perforatum-as-a-treatment-for-premenstrual-dysphoric-2003/
---

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- Does St. John's wort help treat PMDD?

Case report, 2003

# Does St. John's wort help treat PMDD?

In this one case, yes. A woman with PMDD who couldn't tolerate a common antidepressant improved significantly on St. John's wort over at least five months.

 Early or limited evidence

1 woman with PMDD who had stomach side effects from SSRI antidepressants

## What they did

Doctors described a woman with PMDD who was initially treated with an SSRI (a type of antidepressant). Due to intolerable stomach and digestive side effects, she switched to St. John's wort 900 mg per day.

## What they found

The woman had much improvement in her PMDD symptoms, continuing for at least five months.

## What it means for you

St. John's wort may be an option for PMDD patients who cannot tolerate SSRIs because of side effects. This is one case, so we don't know how well it works more broadly or how it compares to other treatments.

900

mg per day of St. John's wort

at least 5

months of improvement

## About the study

Original title St. John's wort (Hypericum perforatum) as a treatment for premenstrual dysphoric disorder: case report Authors Huang KL, Tsai SJ Journal International journal of psychiatry in medicine Year 2003 Study design Case report What was tested St. John's wort 900 mg per day Read the paper [doi.org/10.2190/rery-n6ac-nadc-ehy4](https://doi.org/10.2190/rery-n6ac-nadc-ehy4)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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