--- title: Can sulpiride help women with both PMDD and IBS? | Niyora description: One woman with PMDD and IBS who had not responded to antidepressants, pain medication, or melatonin experienced remission after taking low-dose sulpiride temp url: https://niyora.com/research/papers/successful-treatment-of-premenstrual-dysphoric-disorder-with-irritable-bowel-2024/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Can sulpiride help women with both PMDD and IBS? Review, 2024 # Can sulpiride help women with both PMDD and IBS? One woman with PMDD and IBS who had not responded to antidepressants, pain medication, or melatonin experienced remission after taking low-dose sulpiride temporarily each month. This approach has not yet been tested in research studies. Early or limited evidence 1 woman with PMDD and IBS ## What they did Case report of one woman with PMDD and IBS who had tried multiple treatments without improvement. ## What they found The woman achieved remission of her PMDD symptoms by taking a small dose of sulpiride, stopping on the last day of her period. She was satisfied with the treatment because it addressed her concerns about taking antidepressants. ## What it means for you Low-dose sulpiride taken temporarily each month may be a potential option for women with both PMDD and IBS, particularly those concerned about antidepressants. This is a single case with no comparison group, so it provides only preliminary evidence and cannot prove the treatment works for others. 1 woman in case report ## About the study Original title Successful treatment of Premenstrual dysphoric disorder with irritable bowel syndrome using sulpiride Authors Alageel A Journal European psychiatry : the journal of the Association of European Psychiatrists Year 2024 Study design Review What was tested Low-dose sulpiride taken temporarily each month Open access Yes Read the paper [doi.org/10.21608/scumj.2023.322608](https://doi.org/10.21608/scumj.2023.322608) Original abstract Premenstrual dysphoric disorder (PMDD) is prevalent, more severe than premenstrual syndrome (PMS), and a challenging disorder. The first line of treatment is pharmacotherapy. Non-pharmacological therapy includes aerobic exercise, consumption of complex carbohydrates and frequent meals, relaxation training, light therapy, sleep deprivation, and cognitive-behavioral therapy could be helpful. In this case report, a lady suffering from PMDD and irritable bowel syndrome (IBS) did not respond to antidepressants, painkillers, and melatonin. She used to sit at home and in her room these days, waiting for the PMDD severity to decrease. Her condition reached remission after taking a small dosage of sulpiride and stopped on the last day of the period. The patient is satisfied with the result since concerns about antidepressants are addressed and avoided. This case provides a new approach to using low-dosage sulpiride temporarily every month in patients with both PMDD and IBS. To our knowledge, there have not yet been any studies on this treatment option for PMDD with IBS Reproduced under CC-BY. ## Topics [IBS and gut symptoms](https://niyora.com/research/topics/comorbidity-ibs-gi/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Irritability and anger](https://niyora.com/research/topics/symptom-irritability-anger/)[Sleep and insomnia](https://niyora.com/research/topics/symptom-sleep/)[Cognitive behavioral therapy](https://niyora.com/research/topics/treatment-cbt/)[Exercise and yoga](https://niyora.com/research/topics/treatment-exercise/)[Light therapy and sleep deprivation](https://niyora.com/research/topics/treatment-light-therapy/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Cohort study, 2022 What are PMS and PMDD and how should they be diagnosed and treated? Randomised trial, 2003 What treatments work for PMS and PMDD? Review, 2023 Can herbs and supplements help with PMS symptoms? Survey study, 2023 What is PMS and PMDD, how common are they, and how are they usually treated? Interview study, 1996 Do antidepressants help treat PMDD and similar conditions? Review, 2024 What are the most effective treatments for PMDD? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗