---
title: Does PMDD increase the risk of suicidality? | Niyora
description: Yes. Women with PMDD have significantly higher risk of suicidal thoughts (2.34 times higher), suicide attempts (2.13 times higher), and suicide plans (2.24 ti
url: https://niyora.com/research/papers/suicidality-in-patients-with-premenstrual-dysphoric-disorder-a-systematic-review-2021/
---

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- Does PMDD increase the risk of suicidality?

Systematic review, 2021

# Does PMDD increase the risk of suicidality?

Yes. Women with PMDD have significantly higher risk of suicidal thoughts (2.34 times higher), suicide attempts (2.13 times higher), and suicide plans (2.24 times higher).

 Strong study design

People with PMDD from 6 studies (8,532 total participants)

## What they did

They searched 4 electronic databases up to November 2020, found 6 studies with 8,532 participants total, and combined the results using meta-analysis.

## What they found

Women with PMDD had 2.34 times higher risk of suicidal ideation, 2.13 times higher risk of suicide attempt, and 2.24 times higher risk of suicidal plan. These findings were consistent across studies.

## What it means for you

Women with PMDD should be monitored for signs of suicidal thoughts and behavior. The main limitation is that PMDD diagnosis was provisional in all included studies, not confirmed with full diagnostic criteria.

8,532

total participants across all studies

2.34

times higher risk of suicidal ideation

2.13

times higher risk of suicide attempt

## About the study

Original title Suicidality in patients with premenstrual dysphoric disorder-A systematic review and meta-analysis Authors Yan H, Ding Y, Guo W Journal Journal of affective disorders Year 2021 Study design Systematic review What was tested N/A - observational study Read the paper [doi.org/10.1016/j.jad.2021.08.082](https://doi.org/10.1016/j.jad.2021.08.082)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Suicidality](https://niyora.com/research/topics/symptom-suicidality/)

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## Related studies

Interview study, 2025

How common is suicidal thinking in women with PMDD?

Systematic review, 2021

Are women with PMS or PMDD more likely to think about or attempt suicide?

Survey study, 2026

Are PMS and PMDD linked to suicidal thoughts and violence toward family?

Cohort study, 2026

Does suicidal thinking and self-harm follow the menstrual cycle in PMDD?

Cohort study, 2023

Does the menstrual cycle affect how often women have suicidal thoughts?

Randomised trial, 2022

Do hormone pills prevent suicidal thoughts from getting worse around menstruation?

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