--- title: Does sumatriptan-naproxen help women with period migraines and period pain function better? description: Yes, women given the combination drug reported higher satisfaction, better work productivity, and less functional disability compared to placebo at 24 hours. url: https://niyora.com/research/papers/sumatriptan-naproxen-sodium-for-menstrual-migraine-and-dysmenorrhea-satisfaction-2011/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does sumatriptan-naproxen help women with period migraines and period pain function better? Randomised trial, 2011 # Does sumatriptan-naproxen help women with period migraines and period pain function better? Yes, women given the combination drug reported higher satisfaction, better work productivity, and less functional disability compared to placebo at 24 hours. Moderate study design Women with menstrual migraine and period pain across multiple centers ## What they did Two identical studies in multiple centers randomly assigned women with period migraines and period pain to receive either a single tablet of sumatriptan 85 mg with naproxen sodium 500 mg or placebo to treat one migraine attack. Researchers measured satisfaction, work productivity, and functional ability. ## What they found Women on the combination drug reported significantly higher satisfaction at 24 hours for efficacy, functionality, and ease of use. They had lower lost-time equivalents in work and leisure and lower rates of functional disability compared to placebo. There were minimal side effects with either treatment. ## What it means for you The combination drug helps women feel satisfied with treatment and return to normal activities during period migraines. The study examined only one migraine attack per woman, so we do not know if benefits continue over longer periods. 85 mg / 500 mg Sumatriptan and naproxen sodium doses P < .001 Significance for satisfaction P = .003 Significance for lost work time ## About the study Original title Sumatriptan-naproxen sodium for menstrual migraine and dysmenorrhea: satisfaction, productivity, and functional disability outcomes Authors Cady RK, Diamond ML, Diamond MP et al. Journal Headache Year 2011 Study design Randomised trial What was tested Sumatriptan 85 mg plus naproxen sodium 500 mg as a single tablet versus placebo Open access Yes Read the paper [doi.org/10.1111/j.1526-4610.2011.01894.x](https://doi.org/10.1111/j.1526-4610.2011.01894.x) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Dysmenorrhea and period pain](https://niyora.com/research/topics/condition-dysmenorrhea/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Diuretics and other drugs](https://niyora.com/research/topics/treatment-diuretics-other-drugs/)[Migraine](https://niyora.com/research/topics/comorbidity-migraine/)[Work and productivity](https://niyora.com/research/topics/life-area-work/)[Quality of life and daily functioning](https://niyora.com/research/topics/life-area-quality-of-life/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Survey study, 1999 Do cyclical behavioral changes happen in women with mental disabilities, and what helps? Systematic review, 2025 Does digital healthcare help manage period pain and PMS? Randomised trial, 2014 Does the combination of sumatriptan and naproxen sodium reduce menstrual symptoms and migraine? Survey study, 2026 Are menstrual characteristics linked to depression and anxiety in teenage girls? Survey study, 2025 How do employed women seek relief for premenstrual and menstrual symptoms at work? Survey study, 2018 How common are premenstrual symptoms in female workers, and does exercise help? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗