---
title: Do women with PMS have abnormal automatic nerve function? | Niyora
description: No significant differences were found in sympathetic nerve function between women with PMS and healthy women across their cycle. This suggests PMS is not caus
url: https://niyora.com/research/papers/sympathetic-skin-response-in-premenstrual-syndrome-2005/
---

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- Do women with PMS have abnormal automatic nerve function?

Non-randomised trial, 2005

# Do women with PMS have abnormal automatic nerve function?

No significant differences were found in sympathetic nerve function between women with PMS and healthy women across their cycle. This suggests PMS is not caused by problems in this particular automatic nerve system, though only one type of test was measured.

 Early or limited evidence

24 women with PMS and 20 healthy women without PMS, ages 22-34

## What they did

A nonrandomized trial comparing sympathetic skin response (a test of automatic nerve function) in 24 women with PMS and 20 healthy controls, ages 22-34. Testing was done twice: during the follicular and late luteal phases of the menstrual cycle.

## What they found

Amplitude and latency values of sympathetic skin response during both follicular and late luteal phases were statistically similar between the PMS group and control group. No differences were found in measurements from three body regions (palms, soles, genital area).

## What it means for you

This test did not identify automatic nerve system differences that might explain PMS. However, this was only one type of nerve function test, so other mechanisms may still be involved. The study was small with 24 women in the PMS group.

24

women with PMS

20

control women

25±3

mean age (years)

## About the study

Original title Sympathetic skin response in premenstrual syndrome Authors Ozisik HI, Kamisli O, Karlidag R et al. Journal Clinical autonomic research : official journal of the Clinical Autonomic Research Society Year 2005 Study design Non-randomised trial Participants 24 What was tested None; measurement of nerve function Read the paper [doi.org/10.1007/s10286-005-0281-8](https://doi.org/10.1007/s10286-005-0281-8)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Bloating, breast tenderness and physical symptoms](https://niyora.com/research/topics/symptom-physical-symptoms/)

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