---
title: Does lisuride maleate help premenstrual breast pain? | Niyora
description: Yes. Lisuride maleate significantly reduced premenstrual breast pain compared to placebo, with no significant side effects reported.
url: https://niyora.com/research/papers/symptomatic-treatment-of-premenstrual-mastalgia-in-premenopausal-women-with-2001/
---

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- Does lisuride maleate help premenstrual breast pain?

Randomised trial, 2001

# Does lisuride maleate help premenstrual breast pain?

Yes. Lisuride maleate significantly reduced premenstrual breast pain compared to placebo, with no significant side effects reported.

 Moderate study design

60 premenopausal women with premenstrual breast pain

## What they did

A double-blind study where 60 women with premenstrual breast pain took either 0.2 mg of lisuride maleate or placebo daily for 2 months. Breast pain was measured on a pain scale.

## What they found

Women taking lisuride had much less breast pain than those on placebo. Prolactin levels (a hormone) dropped in the lisuride group and correlated with pain relief.

## What it means for you

This drug may help with breast pain before your period. The study was small with only 30 women per group, so larger studies are needed to confirm it works.

0.2 mg

Daily dose of lisuride

2 months

Treatment duration

30

Women per group

## About the study

Original title Symptomatic treatment of premenstrual mastalgia in premenopausal women with lisuride maleate: a double-blind placebo-controlled randomized study Authors Kaleli S, Aydin Y, Erel CT et al. Journal Fertility and sterility Year 2001 Study design Randomised trial Participants 30 What was tested Lisuride maleate 0.2 mg daily or placebo Open access Yes Read the paper [doi.org/10.1016/s0015-0282(01)01668-5](https://doi.org/10.1016/s0015-0282(01)01668-5)

## Topics

[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/)[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Bloating, breast tenderness and physical symptoms](https://niyora.com/research/topics/symptom-physical-symptoms/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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