---
title: Is low magnesium linked to premenstrual syndrome? | Niyora
description: No clear link was found between magnesium levels and PMS overall. Studies outside the United States found lower magnesium during the luteal phase in women wit
url: https://niyora.com/research/papers/the-association-between-serum-magnesium-and-premenstrual-syndrome-a-systematic-2019/
---

- [Niyora](https://niyora.com/)
- [Research](https://niyora.com/research/)
- [Library](https://niyora.com/research/library/)
- Is low magnesium linked to premenstrual syndrome?

Systematic review, 2019

# Is low magnesium linked to premenstrual syndrome?

No clear link was found between magnesium levels and PMS overall. Studies outside the United States found lower magnesium during the luteal phase in women with PMS, but the practical significance is unclear.

 Moderate study design

Studies of women with and without premenstrual syndrome measuring blood magnesium

## What they did

Systematic review and meta-analysis of 13 observational studies (from 196 identified) examining magnesium levels and PMS, searching medical databases through January 2019.

## What they found

No significant association between serum magnesium and PMS in the overall analysis. In studies conducted outside the US, serum magnesium was lower in the luteal phase in women with PMS. Heterogeneity between studies suggests results should be interpreted cautiously.

## What it means for you

Magnesium levels do not appear to be a major PMS factor in most populations. Findings may vary by region or measurement methods. Larger, well-designed clinical trials are needed to confirm whether magnesium treatment helps PMS.

13

studies included of 196

-0.04

mean magnesium difference overall

-0.37

mean difference in non-US studies

## About the study

Original title The Association Between Serum Magnesium and Premenstrual Syndrome: a Systematic Review and Meta-Analysis of Observational Studies Authors Moslehi M, Arab A, Shadnoush M et al. Journal Biological trace element research Year 2019 Study design Systematic review What was tested None, observational studies Read the paper [doi.org/10.1007/s12011-019-01672-z](https://doi.org/10.1007/s12011-019-01672-z)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Magnesium](https://niyora.com/research/topics/treatment-magnesium/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Systematic review, 2025

Do nutritional interventions help with emotional symptoms of PMS?

Systematic review, 2013

Does Vitex (chaste tree) help PMS and PMDD symptoms?

Systematic review, 2009

Which herbs, vitamins and minerals help treat PMS?

Systematic review, 2007

What treatments work for premenstrual syndrome?

Randomised trial, 2003

What treatments work for PMS and PMDD?

Randomised trial, 2003

What complementary and alternative medicines help with women's reproductive health issues?

Ask AI about this page

Copy prompt

ChatGPT

↗

Claude

↗

Perplexity

↗

Google AI Mode

↗

Grok

↗