---
title: Does vitamin E help premenstrual syndrome symptoms? | Niyora
description: Yes. Vitamin E significantly improved three of the four classes of PMS symptoms over two months, better than placebo.
url: https://niyora.com/research/papers/the-effect-of-alpha-tocopherol-on-premenstrual-symptomatology-a-double-blind-1983/
---

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- Does vitamin E help premenstrual syndrome symptoms?

Randomised trial, 1983

# Does vitamin E help premenstrual syndrome symptoms?

Yes. Vitamin E significantly improved three of the four classes of PMS symptoms over two months, better than placebo.

 Moderate study design

75 women with benign breast disease and premenstrual syndrome symptoms

## What they did

A double-blind, randomized dose-response study where 75 women with benign breast disease received placebo or vitamin E (150, 300, or 600 IU per day) for two months and rated their PMS symptoms before and after.

## What they found

Vitamin E had a significantly greater effect than placebo, improving three of the four classes of PMS symptoms.

## What it means for you

Vitamin E supplementation may help women with severe PMS symptoms. The women studied had benign breast disease, which may not represent all women with PMS. Only two months of follow-up is relatively short.

75

women studied

3 of 4

symptom classes improved

2 months

treatment duration

## About the study

Original title The effect of alpha-tocopherol on premenstrual symptomatology: a double-blind study Authors London RS, Sundaram GS, Murphy L et al. Journal Journal of the American College of Nutrition Year 1983 Study design Randomised trial Participants 75 What was tested Alpha-tocopherol 150, 300, or 600 IU per day or placebo for two months Read the paper [doi.org/10.1080/07315724.1983.10719916](https://doi.org/10.1080/07315724.1983.10719916)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Vitamin E](https://niyora.com/research/topics/treatment-vitamin-e/)

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