---
title: Does calcium supplementation reduce PMS symptoms? | Niyora
description: Yes, calcium reduced PMS severity compared to placebo (p=0.002) but worked about as well as other treatments. We can be fairly confident it helps, but it may
url: https://niyora.com/research/papers/the-effect-of-calcium-on-premenstrual-syndrome-a-meta-analysis-study-2025/
---

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- Does calcium supplementation reduce PMS symptoms?

Systematic review, 2025

# Does calcium supplementation reduce PMS symptoms?

Yes, calcium reduced PMS severity compared to placebo (p=0.002) but worked about as well as other treatments. We can be fairly confident it helps, but it may not be uniquely effective.

 Strong study design

Participants in 6 randomized controlled trials testing calcium for PMS

## What they did

Systematic review and meta-analysis of 6 randomized controlled trials published 2013-2020. Researchers compared calcium supplementation to control groups or other treatments to see if it reduced PMS symptoms.

## What they found

Calcium significantly reduced PMS severity compared to control groups (p=0.002). However, calcium was not more effective than other treatments (p=0.416).

## What it means for you

Calcium appears helpful for PMS compared to doing nothing, but it works about as well as other treatments. It may be a useful option for women looking for a non-drug approach. Limited by the small number of studies (only 6) and lack of detailed information about doses or duration.

6

Randomized trials reviewed

p=0.002

Calcium vs control (significant)

p=0.416

Calcium vs other treatments (not significant)

## About the study

Original title The Effect of Calcium on Premenstrual Syndrome: A Meta-Analysis Study Authors Kevser İlçioğlu, Bilge Nur Yıldırım Bayraktar, Ahsen Demirhan Kayacık Journal Journal of Clinical Medicine of Kazakhstan Year 2025 Study design Systematic review What was tested Calcium supplementation Open access Yes Read the paper [doi.org/10.23950/jcmk/15827](https://doi.org/10.23950/jcmk/15827) Original abstract

Aims This study systematically reviewed the available randomised controlled trials to elucidate the general relationship between calcium and PMS. Material and Methods Meta-analysis followed PRISMA guidelines using the PICOS format, considering CONSORT recommendations. Searches were performed in PubMed, Web of Science, Google Scholar, and Scopus databases between 02.11.2022- 02.12.2022 using the keywords "premenstrual syndrome and calcium" and "premenstrual tension and calcium" and "premenstrual dysphoric disorder and calcium". Results This systematic review and meta-analysis included six randomised controlled trials published between 2013 and 2020. According to the pooled results of the six studies, calcium reduced the severity of PMS complaints (p=0.002; I2 = 76.2%) when calcium administration was compared with the control group for the reduction of PMS complaints. On the other hand, the severity of PMS complaints did not change when calcium administration for the reduction of PMS complaints was compared with other treatments (p=0.416; I2 = 54.7%). Conclusions This study showed that calcium effectively reduced the severity of PMS complaints compared to the control groups. In contrast, the severity of PMS complaints did not change when other treatments and calcium administration were compared.

Reproduced under CC-BY.

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Calcium](https://niyora.com/research/topics/treatment-calcium/)

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