---
title: Does calcium and vitamin D supplementation reduce premenstrual symptoms and depression?
description: Calcium and vitamin D together did not significantly reduce PMS or depression symptoms in this study. The study was very small with no control group, making t
url: https://niyora.com/research/papers/the-effect-of-combined-calcium-and-vitamin-d-supplementation-on-premenstrual-2017/
---

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- Does calcium and vitamin D supplementation reduce premenstrual symptoms and depression?

Survey study, 2017

# Does calcium and vitamin D supplementation reduce premenstrual symptoms and depression?

Calcium and vitamin D together did not significantly reduce PMS or depression symptoms in this study. The study was very small with no control group, making the results unreliable.

 Early or limited evidence

23 healthy women with average age 22.2 years

## What they did

Researchers studied 23 healthy women with an average age of 22.2 years. The women took calcium (600mg) and vitamin D (400IU) supplementation. The researchers measured PMS symptoms and depression before and after supplementation using standard questionnaires.

## What they found

Before supplementation, 60.9% of women (14 out of 23) met criteria for PMS and 26.1% (6 out of 23) had depression symptoms. After supplementation, 52.2% (12 out of 23) had PMS symptoms and 17.4% (4 out of 23) had depression symptoms. The reduction in symptoms was 8.7% in both cases, but this reduction was not statistically significant, meaning it could have been due to chance. Five women had both PMS and depression before supplementation, and only two had both after.

## What it means for you

This study found no clear benefit from taking calcium and vitamin D together for PMS or depression. The study was very small with no comparison group, so these results cannot be trusted. The authors note that longer treatment duration and higher doses might be needed.

60.9%

With PMS before supplementation

52.2%

With PMS after supplementation

8.7%

Reduction in symptoms (not significant)

## About the study

Original title The Effect of Combined Calcium and Vitamin D Supplementation on Premenstrual Symptoms and Depression Authors Armağan Aytuğ Yürük, Funda Tamer, Reyhan Nergiz‐Unal Journal The FASEB Journal Year 2017 Study design Survey study Participants 14 What was tested Calcium (600mg) and vitamin D (400IU) supplementation Read the paper [doi.org/10.1096/fasebj.31.1_supplement.799.3](https://doi.org/10.1096/fasebj.31.1_supplement.799.3)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Calcium](https://niyora.com/research/topics/treatment-calcium/)[Vitamin D](https://niyora.com/research/topics/treatment-vitamin-d/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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