---
title: Does progesterone treatment change hormone binding in severe PMS?
description: Yes, progesterone increased SHBG binding capacity in a dose-dependent way. Higher doses produced larger increases. The abstract does not say if this helped sy
url: https://niyora.com/research/papers/the-effect-of-progesterone-administration-on-sex-hormone-binding-globulin-1984/
---

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- Does progesterone treatment change hormone binding in severe PMS?

Non-randomised trial, 1984

# Does progesterone treatment change hormone binding in severe PMS?

Yes, progesterone increased SHBG binding capacity in a dose-dependent way. Higher doses produced larger increases. The abstract does not say if this helped symptoms.

 Early or limited evidence

31 women with severe premenstrual syndrome

## What they did

Gave 31 women with severe PMS different doses of progesterone (400 mg, 800 mg, or 1200 mg daily) and measured changes in SHBG binding capacity.

## What they found

Baseline SHBG binding capacity was 30.2 nmol DHT bound/l. After 400 mg progesterone it rose to 45.11. After 800 mg it rose to 64.75. After 1200 mg it rose to 78.5.

## What it means for you

Progesterone increases SHBG in women with severe PMS in a dose-dependent way. The abstract does not explain whether this leads to symptom relief or whether these doses are practical.

31

Women with severe PMS

30.2

Baseline SHBG (nmol DHT bound/l)

78.5

SHBG at 1200 mg progesterone (nmol DHT bound/l)

## About the study

Original title The effect of progesterone administration on sex hormone binding globulin binding capacity in women with severe premenstrual syndrome Authors Dalton ME Journal Journal of steroid biochemistry Year 1984 Study design Non-randomised trial Participants 30 What was tested Progesterone at three daily doses: 400 mg, 800 mg, or 1200 mg Read the paper [doi.org/10.1016/0022-4731(84)90249-8](https://doi.org/10.1016/0022-4731(84)90249-8)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)

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