--- title: Does wheat germ extract reduce PMS symptoms? | Niyora description: Yes. Wheat germ extract reduced physical, psychological, and overall PMS symptoms significantly more than placebo, with about 63-66% improvement. url: https://niyora.com/research/papers/the-effect-of-wheat-germ-extract-on-premenstrual-syndrome-symptoms-2015/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does wheat germ extract reduce PMS symptoms? Randomised trial, 2015 # Does wheat germ extract reduce PMS symptoms? Yes. Wheat germ extract reduced physical, psychological, and overall PMS symptoms significantly more than placebo, with about 63-66% improvement. Moderate study design 84 women working at hospital clinics in Iran with PMS ## What they did Triple-blind randomized trial with 84 women at hospital clinics in Iran. Two groups received either wheat germ extract capsules (400 mg) or placebo three times daily from day 16 of the menstrual cycle until day 5 of the next cycle, for 2 months. ## What they found Wheat germ extract reduced physical symptoms by 63.56%, psychological symptoms by 66.30%, and overall symptoms by 64.99%, significantly more than placebo (p < 0.001). ## What it means for you Wheat germ extract appears to help both the physical and emotional symptoms of PMS. The study was conducted in hospital workers in Iran, so it's unclear whether results apply to other populations or settings. 63.56% Physical symptom reduction 66.30% Psychological symptom reduction 84 Women in study ## About the study Original title The effect of wheat germ extract on premenstrual syndrome symptoms Authors Ataollahi M, Akbari SA, Mojab F et al. Journal Iranian journal of pharmaceutical research : IJPR Year 2015 Study design Randomised trial Participants 84 What was tested Wheat germ extract capsules (400 mg) or placebo, three times daily from day 16 of cycle to day 5 of next cycle for 2 months Open access Yes Read the paper [https://pubmed.ncbi.nlm.nih.gov/25561922/](https://pubmed.ncbi.nlm.nih.gov/25561922/) Original abstract Pre-menstrual syndrome is one of the most common disorders in women and impairs work and social relationships. Several treatment modalities have been proposed including herbal medicines. Considering the properties of wheat germ, this study aimed to determine the effects of wheat germ extract on the symptoms of premenstrual syndrome. This triple blind clinical trial was conducted on 84 women working in hospitals affiliated to Hamadan University of Medical Sciences. Subjects completed daily symptom record form for two consecutive months. After definitive diagnosis of premenstrual syndrome, they were randomly divided into two groups of 50 people. Then, for two consecutive months, 400 mg capsules of wheat germ extract or placebo were used three times a day, from day 16 until day 5 of the next menstrual cycle. Wheat germ significantly reduced physical symptoms (63.56%), psychological symptoms (66.30%), and the general score (64.99%). Although the severity of symptoms decreased in both groups, this reduction was more significant in the wheat germ extract group (p < 0.001). On the other hand, physical symptoms decreased only in the wheat germ extract (p < 0.001) and there was no statistically significant difference in the placebo group. No complications were observed in any of the groups. It seems that using wheat germ extract reduces general, psychological and physical symptoms. Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Systematic review, 2026 Which traditional Chinese medicine treatments work best for PMS? Randomised trial, 2025 Do essential oils reduce PMS symptoms? Randomised trial, 2025 Which is more effective for PMS - Vitagnus, soy, or both together? Randomised trial, 2025 Does the PMSoff supplement help PMS and PMDD symptoms? Randomised trial, 2024 Is Jiawei Xiaoyao pill effective and safe for treating premenstrual syndrome? Randomised trial, 2024 Is Ganyushu Granule effective and safe for premenstrual syndrome? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗