--- title: Does zinc supplementation reduce PMS symptoms in women? | Niyora description: Yes. Daily zinc supplementation for 24 weeks significantly reduced multiple PMS symptoms including anger, anxiety, depressed mood, and physical symptoms like url: https://niyora.com/research/papers/the-effect-of-zinc-supplementation-on-the-improvement-of-premenstrual-symptoms-2023/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does zinc supplementation reduce PMS symptoms in women? Randomised trial, 2023 # Does zinc supplementation reduce PMS symptoms in women? Yes. Daily zinc supplementation for 24 weeks significantly reduced multiple PMS symptoms including anger, anxiety, depressed mood, and physical symptoms like breast tenderness and bloating compared to placebo. Strong study design 69 female university students aged 18-35 in Iran with PMS ## What they did Researchers conducted a triple-masked, randomized, placebo-controlled trial with 69 female university students aged 18-35 in Iran. One group received 220 mg of elemental zinc daily (33 students) and the other group received placebo (36 students) for 24 weeks. PMS symptoms were measured using a standardized questionnaire at the start and end of the study. ## What they found After 24 weeks, the zinc group showed significant decreases in anger, anxiety, depressed mood, overeating, breast tenderness, headaches, muscle pain, bloating, and weight gain compared to placebo (P < 0.001). The zinc group also showed significant improvement in relationships with friends, classmates, and coworkers compared to placebo (p = 0.003). ## What it means for you Zinc appears to be an inexpensive and simple treatment that can reduce both physical and emotional symptoms of PMS. The study is limited by its relatively small sample size and being conducted in only one country. More research is needed to confirm these findings with larger groups. 69 female university students 220 mg elemental zinc daily 24 weeks of treatment ## About the study Original title The Effect of Zinc Supplementation on the Improvement of Premenstrual Symptoms in Female University Students: a Randomized Clinical Trial Study Authors Ahmadi M, Khansary S, Parsapour H et al. Journal Biological trace element research Year 2023 Study design Randomised trial Participants 36 What was tested 220 mg elemental zinc daily for 24 weeks Read the paper [doi.org/10.1007/s12011-022-03175-w](https://doi.org/10.1007/s12011-022-03175-w) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Bloating, breast tenderness and physical symptoms](https://niyora.com/research/topics/symptom-physical-symptoms/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Zinc and iron](https://niyora.com/research/topics/treatment-zinc-iron/)[Students and academic performance](https://niyora.com/research/topics/life-area-education/)[Adolescents and young people](https://niyora.com/research/topics/life-area-adolescents/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Randomised trial, 2026 Is Pilates exercise more effective than stretching for reducing PMS symptoms? Survey study, 2026 How common is PMDD in Russian medical students, and what are its symptoms? Survey study, 2025 What factors are linked to PMS in female graduate students? Survey study, 2024 Is there a link between body weight and PMS? Survey study, 2020 Do girls with type 1 diabetes experience different PMS than other girls? Survey study, 2015 How common is PMS in teenage school girls in an urban city in India? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗