---
title: Do antidepressants work for PMDD? | Niyora
description: Yes, according to this review. Serotonergic antidepressants have shown effectiveness for premenstrual dysphoric disorder, whether taken every day or just duri
url: https://niyora.com/research/papers/the-evaluation-and-management-of-depression-in-women-across-the-life-span-2001/
---

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- Do antidepressants work for PMDD?

Survey study, 2001

# Do antidepressants work for PMDD?

Yes, according to this review. Serotonergic antidepressants have shown effectiveness for premenstrual dysphoric disorder, whether taken every day or just during the luteal phase before the period.

 Early or limited evidence

Women across the lifespan, with focus on reproductive years

## What they did

A review article discussing depression in women at different life stages, including how antidepressants work and how to use them safely during pregnancy and at different ages.

## What they found

Depression is more common in women than men, especially during reproductive years. Depression can occur during the premenstrual period, pregnancy, postpartum, and perimenopause. For PMDD, serotonergic agents have demonstrated efficacy in both full-cycle and luteal-phase dosing strategies. Limited safety data suggest antidepressants pose minimal danger to fetuses or infants.

## What it means for you

Antidepressants appear to help PMDD, and doctors can choose to give them continuously or just during the luteal phase before your period. This is a review article summarizing other people's research rather than new research itself.

## About the study

Original title The evaluation and management of depression in women across the life span Authors Kornstein SG Journal The Journal of clinical psychiatry Year 2001 Study design Survey study What was tested Serotonergic antidepressant medications Read the paper [https://pubmed.ncbi.nlm.nih.gov/11676428/](https://pubmed.ncbi.nlm.nih.gov/11676428/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)[Major depressive disorder](https://niyora.com/research/topics/comorbidity-major-depression/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/)[Pregnancy and postpartum](https://niyora.com/research/topics/comorbidity-postpartum/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Review, 2012

Is depression linked to hormonal changes during the menstrual cycle, pregnancy, and menopause?

Review, 2004

How should PMDD be treated with antidepressants?

Survey study, 2002

What treatments work for depression linked to the menstrual cycle and PMDD?

Guideline, 2001

What is the best treatment for PMDD and depression in women?

Non-randomised trial, 2014

Does hormone therapy help women with depression linked to periods and menopause?

Study, 2004

Did SSRIs change what people thought of as depression in women?

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