---
title: What treatments have been proven to work for PMS and PMDD? | Niyora
description: SSRIs and oral contraceptives containing drosperinone have been shown to help PMS and PMDD in clinical trials, but no medication is officially registered for
url: https://niyora.com/research/papers/the-premenstrual-syndrome-2010/
---

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- What treatments have been proven to work for PMS and PMDD?

Randomised trial, 2010

# What treatments have been proven to work for PMS and PMDD?

SSRIs and oral contraceptives containing drosperinone have been shown to help PMS and PMDD in clinical trials, but no medication is officially registered for PMS treatment in the Netherlands.

 Early or limited evidence

Not applicable, review article about PMS and PMDD in general

## What they did

This is a clinical overview article describing PMS and PMDD and reviewing what is known about their causes and treatments. It is not a clinical trial reporting original research results.

## What they found

PMS involves physical and psychological symptoms during the luteal phase that disappear with menstruation. PMDD is similar but with more psychological symptoms. The cause is unknown. Randomized placebo-controlled trials have found that SSRIs and oral contraceptives with drosperinone help both conditions.

## What it means for you

This article provides background information rather than original research results. It suggests two types of treatment are supported by evidence but does not provide specific numbers or findings from a single study.

2

minimum menstrual cycles for diagnosis

1 week

minimum symptom-free period required for diagnosis

## About the study

Original title [The premenstrual syndrome] Authors van der Leij F, Schultz WC, van de Wiel H et al. Journal Nederlands tijdschrift voor geneeskunde Year 2010 Study design Randomised trial What was tested Not applicable, review article Read the paper [https://pubmed.ncbi.nlm.nih.gov/20719012/](https://pubmed.ncbi.nlm.nih.gov/20719012/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Oral contraceptives and drospirenone](https://niyora.com/research/topics/treatment-hormonal-contraceptives/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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