---
title: Does stopping hormone production help severe PMS? | Niyora
description: Yes. In this 6-month study of 8 women, a GnRH agonist (which stops ovarian hormone production) relieved both physical and behavioral symptoms. Long-term safet
url: https://niyora.com/research/papers/the-premenstrual-syndrome-effects-of-medical-ovariectomy-1984/
---

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- Does stopping hormone production help severe PMS?

Non-randomised trial, 1984

# Does stopping hormone production help severe PMS?

Yes. In this 6-month study of 8 women, a GnRH agonist (which stops ovarian hormone production) relieved both physical and behavioral symptoms. Long-term safety is unknown.

 Early or limited evidence

8 women with well-characterized premenstrual syndrome

## What they did

A crossover study over 6 months in 8 women with well-characterized PMS who took a gonadotropin-releasing hormone agonist that temporarily stops the ovaries from producing hormones.

## What they found

Physical and behavioral symptoms were relieved by the hormone agonist.

## What it means for you

This approach may help severe PMS in the short term. However, the study was very small (8 women) and long-term safety and the need for prolonged treatment remain unknown.

8

Women studied

6

Months of study

## About the study

Original title The premenstrual syndrome. Effects of "medical ovariectomy" Authors Muse KN, Cetel NS, Futterman LA et al. Journal The New England journal of medicine Year 1984 Study design Non-randomised trial What was tested Gonadotropin-releasing hormone agonist given daily Read the paper [doi.org/10.1056/nejm198411223112104](https://doi.org/10.1056/nejm198411223112104)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)[Surgical menopause](https://niyora.com/research/topics/treatment-surgery/)

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