--- title: Does PMS affect mental health and sleep-wake cycles? | Niyora description: Yes. Women with PMS have significantly higher depression and anxiety than those without PMS. Sleep-wake timing irregularities may also play a role, though the url: https://niyora.com/research/papers/the-relationship-between-premenstrual-syndrome-and-circadian-rhythm-depressive-2025/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does PMS affect mental health and sleep-wake cycles? Cohort study, 2025 # Does PMS affect mental health and sleep-wake cycles? Yes. Women with PMS have significantly higher depression and anxiety than those without PMS. Sleep-wake timing irregularities may also play a role, though the relationship is unclear. Early or limited evidence 98 female nursing students at a university, mean age 21.13 years ## What they did Cross-sectional study of 98 female nursing students with a mean age of 21.13 years. Participants completed the Premenstrual Syndrome Scale to measure PMS severity, Beck Depression Inventory and Beck Anxiety Inventory to measure mood, and questionnaires about chronotype (whether they are morning or evening people) and social jetlag (mismatch between their body clock and daily schedule). ## What they found Students with PMS had significantly higher depression and anxiety scores than those without PMS. PMS presence increased depression scores (odds ratio 1.126) and anxiety scores (odds ratio 1.094). In the group with PMS, higher PMS severity was positively correlated with both social jetlag and anxiety, but there was no clear link between PMS and chronotype or social jetlag alone. ## What it means for you PMS and mental health problems are strongly linked. Sleep-wake timing issues may contribute to worse symptoms when PMS is more severe. This is a very small study of nursing students only, so results may not apply to other women. The study relied on self-reported data, which may introduce bias. 1.126 Depression odds ratio in PMS group 1.094 Anxiety odds ratio in PMS group 0.351 Correlation between PMS severity and social jetlag ## About the study Original title The relationship between premenstrual syndrome and circadian rhythm, depressive mood, and anxiety Authors Yamak ÖA, Şentürk Ş, Kağıtçı M et al. Journal Scientific reports Year 2025 Study design Cohort study Participants 98 What was tested None Open access Yes Read the paper [doi.org/10.1038/s41598-025-23040-9](https://doi.org/10.1038/s41598-025-23040-9) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Sleep and insomnia](https://niyora.com/research/topics/symptom-sleep/)[Relationships and partners](https://niyora.com/research/topics/life-area-relationships/)[Students and academic performance](https://niyora.com/research/topics/life-area-education/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Survey study, 2026 What dietary, lifestyle, and psychological factors are associated with PMS in young women? Case-control study, 2020 Is diet quality lower in teenagers with PMS? Survey study, 2023 Does childhood trauma increase the risk of PMDD? Survey study, 2017 Are PMS symptoms linked to mood disorders and personality? Survey study, 2017 Do women with moderate PMS have more depression, anxiety, stress, and sleep problems than those with mild PMS? Survey study, 2026 Does exercise help college women with period problems and mental health? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗