--- title: Is low vitamin D related to PMS? | Niyora description: No. Although vitamin D deficiency was common in both groups of young Iranian women, there was no difference in vitamin D levels between those with PMS and tho url: https://niyora.com/research/papers/the-relationship-between-serum-vitamin-d-level-and-premenstrual-syndrome-in-2016/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Is low vitamin D related to PMS? Case-control study, 2016 # Is low vitamin D related to PMS? No. Although vitamin D deficiency was common in both groups of young Iranian women, there was no difference in vitamin D levels between those with PMS and those without. Early or limited evidence 82 women in Iran ## What they did Measured vitamin D blood levels in 82 Iranian women and compared them between those with PMS and those without. ## What they found Women with PMS started their periods earlier than those without PMS (p=0.04). Body mass index was similar between groups. Both groups had high rates of vitamin D deficiency, with no significant difference in blood vitamin D levels between the two groups. ## What it means for you This study found no link between vitamin D levels and PMS in young Iranian women, though the deficiency is widespread in this population. The findings may not apply to women in other regions with different sun exposure. 82 Women studied p=0.04 Earlier menarche in PMS group ## About the study Original title The relationship between serum vitamin D level and premenstrual syndrome in Iranian women Authors Rajaei S, Akbari Sene A, Norouzi S et al. Journal International journal of reproductive biomedicine Year 2016 Study design Case-control study Participants 82 What was tested None (observational) Open access Yes Read the paper [doi.org/10.29252/ijrm.14.10.665](https://doi.org/10.29252/ijrm.14.10.665) Original abstract Background: Premenstrual syndrome (PMS) is among the most unfavorable problems in women in reproductive age; however its pathophysiology is still not fully confirmed. Vitamin D as an immunomodulator could prevent inflammatory state before and during menstruation. Objective: The aim was to investigate whether there is any relationship between serum vitamin D levels and PMS. Materials and methods: In total, 82 women participate in this case-control study which was conducted in Shahid Akbar-abadi hospital from November 2013 to March 2015. Categorization was based on an Iranian version of the premenstrual symptoms screening tool (PSST). Levels of 25 hydroxy-vitamin D3 (25OHD) were determined by using 25-OH Vitamin D ELISA kit in luteal phase. Characteristics of participants and vitamin D levels were compared between two groups by using independent sample t-test. Results: Menarche age of women with PMS was significantly lower than normal women (p=0.04). Body mass index was not statistically different between groups. We observed a high rate of vitamin D deficiency and also its severe deficiency in both PMS and non-PMS groups. However, our study demonstrated no significant difference in the levels of serum 25OHD between the two groups. Conclusion: It seems there is no association between PMS and serum levels of vitamin D3; however, the high rate of vitamin D deficiency among young Iranian women emerges special health care considerations in this group. Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Vitamin D](https://niyora.com/research/topics/treatment-vitamin-d/)[Relationships and partners](https://niyora.com/research/topics/life-area-relationships/)[Adolescents and young people](https://niyora.com/research/topics/life-area-adolescents/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Survey study, 2018 Does vitamin D or calcium level affect PMS symptoms and menstrual bleeding? Randomised trial, 2016 Does vitamin D help with PMS mood symptoms in young women with very low vitamin D? Survey study, 2025 What factors affect premenstrual syndrome in teenage girls? Case-control study, 2010 Does vitamin D intake reduce the risk of PMS? Cohort study, 2024 Is there a link between sleep and menstrual problems in teenage girls? Non-randomised trial, 2026 Do dietary changes or sun exposure reduce PMS symptoms in adolescent girls? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗