--- title: Can an extract from Codonopsis lanceolata peel help with PMS? description: In lab and mouse studies, this plant peel extract changed hormone, immune and gut bacteria levels in ways that may relate to PMS, but this has not yet been te url: https://niyora.com/research/papers/therapeutic-potential-of-i-codonopsis-lanceolata-i-peel-extract-in-premenstrual-2025/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Can an extract from Codonopsis lanceolata peel help with PMS? Lab study, 2025 # Can an extract from Codonopsis lanceolata peel help with PMS? In lab and mouse studies, this plant peel extract changed hormone, immune and gut bacteria levels in ways that may relate to PMS, but this has not yet been tested in women. Early or limited evidence Immune cells and pituitary cells in lab dishes, and mice given a drug to raise prolactin ## What they did Researchers tested Codonopsis lanceolata peel extract (CPE) in lab dishes with immune cells and hormone-making pituitary cells, and in mice given a drug to cause high prolactin levels, looking at hormone, inflammation and gut bacteria changes. ## What they found CPE lowered nitric oxide and reduced IL-6 and TNF-alpha (inflammation markers) in immune cells, and reduced prolactin release from hormone cells. In mice with high prolactin, CPE lowered prolactin, PGE2 and inflammatory markers, and raised PGE1 and FSH. It also increased helpful gut bacteria like Lactobacillus and Bifidobacterium and reduced bacteria linked to inflammation. ## What it means for you This early work hints that the extract might help with the hormone and inflammation changes seen in PMS by affecting gut bacteria too, but it was only done in cells and mice, not in women with PMS, so it cannot yet be recommended as a treatment. ## About the study Original title Therapeutic potential of Codonopsis lanceolata peel extract in premenstrual syndrome: insights into hormonal, immune, and microbial interactions Authors Gwon H, Kim HJ, Jeong JW et al. Journal Food science and biotechnology Year 2025 Study design Lab study What was tested Codonopsis lanceolata peel extract (CPE) Open access Yes Read the paper [doi.org/10.1007/s10068-025-02003-w](https://doi.org/10.1007/s10068-025-02003-w) Original abstract This study investigated the therapeutic potential of Codonopsis lanceolata peel extract (CPE) for premenstrual syndrome (PMS). The focus was on hormonal, immune, and microbial pathways. In vitro, CPE reduced nitric oxide production and suppressed IL-6 and TNF-α expression in LPS-stimulated macrophages. In pituitary GH3 cells stimulated with estradiol, CPE inhibited prolactin secretion. In a metoclopramide (MCP)-induced hyperprolactinemia mouse model, CPE decreased serum prolactin, PGE2, and inflammatory cytokines, while increasing PGE1 and FSH levels. Microbiome analysis showed that CPE enriched beneficial genera such as Lactobacillus and Bifidobacterium and reduced pro-inflammatory taxa including Oscillibacter and Desulfovibrionaceae . These microbial shifts were associated with improved inflammatory and hormonal markers. Overall, these findings suggest that CPE alleviates PMS symptoms by modulating endocrine function and regulating gut microbiota. Supplementary information: The online version contains supplementary material available at 10.1007/s10068-025-02003-w. Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[IBS and gut symptoms](https://niyora.com/research/topics/comorbidity-ibs-gi/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Randomised trial, 2024 Does a banana drink with egg white reduce PMDD symptoms and improve mood? Study, 2022 Do women with PMS have different gut bacteria? Survey study, 2022 How common are premenstrual symptoms, and do they change with age? Survey study, 2021 Is there a reliable tool to measure menstrual distress? Randomised trial, 2019 Does yoga reduce anxiety in women with PMS? Review, 2015 Does inflammation during menstruation cause PMS and related symptoms? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗