---
title: Do women with PMS have thyroid problems? | Niyora
description: No. Women with PMS have similar thyroid hormone and prolactin levels to healthy women in both the follicular and luteal phases of their cycle.
url: https://niyora.com/research/papers/thyrotropin-and-prolactin-responses-to-thyrotropin-releasing-hormone-in-1989/
---

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- Do women with PMS have thyroid problems?

Lab study, 1989

# Do women with PMS have thyroid problems?

No. Women with PMS have similar thyroid hormone and prolactin levels to healthy women in both the follicular and luteal phases of their cycle.

 Early or limited evidence

15 women with PMS and 19 age-matched healthy women

## What they did

Researchers measured thyroid and prolactin hormones in 15 women with PMS and 19 healthy women during different cycle phases. They also tested how these hormones responded when given a hormone called TRH.

## What they found

Thyroid hormone and prolactin levels were similar between groups in both the follicular and luteal phases. When given TRH, both groups showed virtually identical hormone responses.

## What it means for you

Thyroid problems do not appear to cause PMS. Taking thyroid hormones to treat PMS is not supported by this evidence. This is a small study so larger research would strengthen the finding.

15

women with PMS

19

healthy women

## About the study

Original title Thyrotropin and prolactin responses to thyrotropin-releasing hormone in premenstrual syndrome Authors Casper RF, Patel-Christopher A, Powell AM Journal The Journal of clinical endocrinology and metabolism Year 1989 Study design Lab study Participants 15 Read the paper [doi.org/10.1210/jcem-68-3-608](https://doi.org/10.1210/jcem-68-3-608)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Cognition, concentration and memory](https://niyora.com/research/topics/symptom-cognition/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)[Thyroid disorders](https://niyora.com/research/topics/comorbidity-thyroid/)

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Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Non-randomised trial, 2025

What treatments help PMS and PMDD?

Case-control study, 2012

Do women with mood symptoms linked to their menstrual cycle have different thyroid hormone levels?

Randomised trial, 2006

Do women with PMDD and depression process progesterone differently than others?

Randomised trial, 2003

Does leptin explain why women develop PMS symptoms?

Lab study, 2025

Can genistein reduce anxiety in the premenstrual phase without raising estrogen?

Survey study, 2014

Does allopregnanolone, a progesterone metabolite, cause mood problems in PMDD?

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