---
title: Can very small doses of progesterone clear premenstrual symptoms?
description: Yes. In women with PMS, 96% had symptoms completely or almost completely clear within 30 minutes when given a dose of progesterone determined by skin testing.
url: https://niyora.com/research/papers/treatment-of-common-gynecologic-endocrinologic-symptoms-by-allergy-management-1982/
---

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- Can very small doses of progesterone clear premenstrual symptoms?

Study, 1982

# Can very small doses of progesterone clear premenstrual symptoms?

Yes. In women with PMS, 96% had symptoms completely or almost completely clear within 30 minutes when given a dose of progesterone determined by skin testing.

 Moderate study design

132 women with progesterone-related symptoms from menstrual cycle, pregnancy, or hormone use.

## What they did

132 women with progesterone-related symptoms received very small doses of progesterone. Each woman's dose was first determined by skin testing. The study used a single-blind design where women did not know whether they were getting the treatment or placebo.

## What they found

In women with PMS, 96% had symptoms completely or almost completely clear, usually within 30 minutes. Other conditions also improved: 100% with pregnancy nausea and vomiting, and 84% with painful periods.

## What it means for you

Very small doses of progesterone determined by skin testing may clear premenstrual symptoms quickly in most women. The doses used were extremely small, ranging from 0.0016 mg or less up to a maximum of 2.5 mg. The study design helped rule out placebo effect.

96%

Women with PMS whose symptoms cleared

132

Women studied

30 minutes

Time to symptom clearing

## About the study

Original title Treatment of common gynecologic-endocrinologic symptoms by allergy management procedures Authors Mabray CR, Burditt ML, Martin TL et al. Journal Obstetrics and gynecology Year 1982 Study design Study Participants 132 What was tested Skin-tested doses of progesterone. Read the paper [https://pubmed.ncbi.nlm.nih.gov/7200220/](https://pubmed.ncbi.nlm.nih.gov/7200220/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Dysmenorrhea and period pain](https://niyora.com/research/topics/condition-dysmenorrhea/)[Pregnancy and postpartum](https://niyora.com/research/topics/comorbidity-postpartum/)

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