--- title: Does Sepranolone reduce symptoms of severe premenstrual syndrome (PMDD)? description: Yes, Sepranolone reduced PMDD symptoms significantly more than placebo, with severe symptom scores dropping by 75% compared to 47% for placebo in women who co url: https://niyora.com/research/papers/treatment-of-premenstrual-dysphoric-disorder-with-the-gaba-a-receptor-modulating-2017/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does Sepranolone reduce symptoms of severe premenstrual syndrome (PMDD)? Randomised trial, 2017 # Does Sepranolone reduce symptoms of severe premenstrual syndrome (PMDD)? Yes, Sepranolone reduced PMDD symptoms significantly more than placebo, with severe symptom scores dropping by 75% compared to 47% for placebo in women who completed treatment correctly. However, implementation challenges limit confidence in the results. Moderate study design 126 women with PMDD across 10 centers in Sweden ## What they did This was a two-part study across 10 Swedish centers. First, 26 healthy women tested the drug's safety and dosing. Then 126 women with PMDD were randomly assigned to receive Sepranolone (10 or 16mg injected under the skin every other day during the luteal phase) or placebo for one menstrual cycle. ## What they found Of 126 women, 106 completed the study. Sepranolone reduced total symptoms significantly more than placebo (p=0.041). Mood symptoms showed borderline significance (p=0.051). In the subgroup of 60 women with pure PMDD who took medication correctly, Sepranolone reduced symptom scores by 75% compared to 47% with placebo. ## What it means for you Sepranolone appears to reduce PMDD symptoms significantly when injected during the luteal phase. However, 19 women showed symptoms at the wrong time suggesting other conditions, and 27 did not take medication correctly. Larger, better-controlled studies are needed before it can be used routinely. 126 women with PMDD enrolled 75% symptom reduction with Sepranolone in subset 47% symptom reduction with placebo in subset ## About the study Original title Treatment of premenstrual dysphoric disorder with the GABA A receptor modulating steroid antagonist Sepranolone (UC1010)-A randomized controlled trial Authors Bixo M, Ekberg K, Poromaa IS et al. Journal Psychoneuroendocrinology Year 2017 Study design Randomised trial Participants 60 What was tested Sepranolone (UC1010) 10 or 16mg injected under the skin every other day during the luteal phase Open access Yes Read the paper [doi.org/10.1016/j.psyneuen.2017.02.031](https://doi.org/10.1016/j.psyneuen.2017.02.031) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Irritability and anger](https://niyora.com/research/topics/symptom-irritability-anger/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Oral contraceptives and drospirenone](https://niyora.com/research/topics/treatment-hormonal-contraceptives/)[Neurosteroids (allopregnanolone)](https://niyora.com/research/topics/treatment-neurosteroids/)[Pregnancy and postpartum](https://niyora.com/research/topics/comorbidity-postpartum/)[Quality of life and daily functioning](https://niyora.com/research/topics/life-area-quality-of-life/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Cohort study, 2010 How do anxiety disorders differ across different life stages? Study, 2026 What treatments work for PMDD? Case-control study, 2025 Do certain hormone-related brain chemicals predict how bad premenstrual depression and anxiety will be? Randomised trial, 2023 Does a smartphone app for heart rate variability biofeedback reduce premenstrual and depressive symptoms? Study, 2022 Why do women get PMS and PMDD? Survey study, 2009 Why do some women feel depressed or anxious when progesterone increases before their period? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗