--- title: Does progesterone reduce PMS symptoms in women with polycystic ovary syndrome? description: Yes. Women with PCOS and PMS who took progesterone had significant reductions in depression, anxiety, mood swings, bloating, and several other PMS symptoms co url: https://niyora.com/research/papers/treatment-of-premenstrual-syndrome-with-progesterone-in-women-with-polycystic-2013/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does progesterone reduce PMS symptoms in women with polycystic ovary syndrome? Randomised trial, 2013 # Does progesterone reduce PMS symptoms in women with polycystic ovary syndrome? Yes. Women with PCOS and PMS who took progesterone had significant reductions in depression, anxiety, mood swings, bloating, and several other PMS symptoms compared to placebo. Moderate study design 60 women with both PCOS and PMS, aged 18–35 years ## What they did A randomized double-blind placebo-controlled trial of 60 women aged 18–35 who had both PCOS and PMS. Half received 300 mg progesterone daily in 3 doses from day 15 to day 25 of their cycle, and half received placebo capsules, for 3 months. Symptom severity was measured before treatment and 3 months after. ## What they found 95.5% of participants had 2 or more premenstrual symptoms. The most frequent were depression, anxiety, abdominal bloating, mood swings, and breast tenderness. The progesterone group had statistically significant declines in depression, irritability, anxiety, mood swings, bloating, sleeplessness, feeling hopeless, breast tenderness, and loss of interest in usual activities. ## What it means for you Progesterone treatment reduces multiple PMS symptoms in women with PCOS. However, this study only included women with PCOS, so results may not apply to women without PCOS. The treatment period was 3 months. 60 women with PCOS and PMS 300 mg daily progesterone dose 3 months treatment duration ## About the study Original title Treatment of Premenstrual Syndrome with Progesterone in Women with Polycystic Ovary Syndrome Authors Ibrahim Oguz Karaca Journal Gynecology & Obstetrics Year 2013 Study design Randomised trial Participants 30 What was tested Progesterone 300 mg daily (in 3 doses from day 15–25) for 3 months Read the paper [doi.org/10.4172/2161-0932.1000151](https://doi.org/10.4172/2161-0932.1000151) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Irritability and anger](https://niyora.com/research/topics/symptom-irritability-anger/)[Mood swings and emotion regulation](https://niyora.com/research/topics/symptom-emotional-regulation/)[Sleep and insomnia](https://niyora.com/research/topics/symptom-sleep/)[Bloating, breast tenderness and physical symptoms](https://niyora.com/research/topics/symptom-physical-symptoms/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)[Polycystic ovary syndrome (PCOS)](https://niyora.com/research/topics/comorbidity-pcos/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Randomised trial, 2020 Does progesterone therapy help premenstrual syndrome in women with PCOS? Survey study, 2019 How common is premenstrual syndrome among medical students? Cohort study, 1986 Is PMS mainly about symptoms worsening before your period, or is there more? Survey study, 1982 Are premenstrual and menstrual symptoms separate problems or part of one larger problem? Study, 2026 What are premenstrual syndrome and premenstrual dysphoric disorder? Randomised trial, 2018 Does swimming reduce premenstrual syndrome symptoms? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗