---
title: Does nomegestrol acetate improve menstrual disorders and PMS?
description: Yes, nomegestrol acetate reduced menstrual loss, with results similar to didrogesteron by the end of the study, though the sample was small.
url: https://niyora.com/research/papers/use-of-nomegestrol-acetate-in-the-treatment-of-menstruation-disorders-our-1997/
---

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- Does nomegestrol acetate improve menstrual disorders and PMS?

Randomised trial, 1997

# Does nomegestrol acetate improve menstrual disorders and PMS?

Yes, nomegestrol acetate reduced menstrual loss, with results similar to didrogesteron by the end of the study, though the sample was small.

 Early or limited evidence

56 women aged 22-50 with menstrual disorders or premenstrual syndrome

## What they did

Fifty-six women aged 22-50 with menstrual disorders or PMS were divided into two groups. One group took nomegestrol acetate 5 mg daily, the other took didrogesteron 10 mg twice daily. Both were given for 10 days starting from day 16 of each cycle, for 3 consecutive cycles.

## What they found

After the first cycle, nomegestrol acetate showed higher efficacy in reducing menstrual loss compared to didrogesteron. By the end of the study, results were similar between groups. No pain was reported in either group, and no significant changes in blood tests or clinical parameters occurred.

## What it means for you

Nomegestrol acetate may help reduce menstrual bleeding and PMS symptoms at low doses. The main limits are the small sample size and it was only compared to one other drug, so we cannot be sure if it is better than other options.

56

Women in study

5

Nomegestrol acetate dose (mg daily)

3

Menstrual cycles of treatment

## About the study

Original title [Use of nomegestrol acetate in the treatment of menstruation disorders. Our experience in 56 cases] Authors Persiani P, Radici E, Lombardi PA et al. Journal Minerva ginecologica Year 1997 Study design Randomised trial Participants 56 What was tested Nomegestrol acetate (5 mg daily) vs didrogesteron (10 mg twice daily) Read the paper [https://pubmed.ncbi.nlm.nih.gov/9206771/](https://pubmed.ncbi.nlm.nih.gov/9206771/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Oral contraceptives and drospirenone](https://niyora.com/research/topics/treatment-hormonal-contraceptives/)

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